Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996714360> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1996714360 endingPage "2117" @default.
- W1996714360 startingPage "2113" @default.
- W1996714360 abstract "Because of the potential clinical significance of the report that dexamethasone is a radioprotector of Chinese hamster V-79 cells, the effect of dexamethasone treatment on the radiosensitivity of five other cultured mammalian cell lines (including two human cell lines) was tested and preliminary investigations into the mechanism of protection of V-79 cells were undertaken. In agreement with the published results of others, we found that treatment of V-79 cells with dexamethasone results in a 1.3-fold increase in D0. Conversely, dexamethasone had no effect on the radiosensitivity of Chinese hamster ovary cells, murine fibrosarcoma, rat glioma cells, human diploid fibroblasts, or human mammary carcinoma cells. To study the mechanism of the radioprotective effect of dexamethasone on V-79 cells, the cell cycle was examined. Dexamethasone treatment causes a change in cell cycle distribution in V-79 cells, resulting in a dose-dependent reduced fraction of S-phase and an increased fraction of G1- and G2 + M-phase cells. However, these kinetic changes cannot explain the observed radioprotection of asynchronous populations, since purified G1 cells are more radiosensitive. Furthermore, cells synchronized in G1 by centrifugal elutriation were shown to be protected by dexamethasone to the same extent as was the unsorted population, thereby ruling out the mechanism of protection being a redistribution in the cell cycle." @default.
- W1996714360 created "2016-06-24" @default.
- W1996714360 creator A5011217013 @default.
- W1996714360 creator A5037297048 @default.
- W1996714360 creator A5054855052 @default.
- W1996714360 creator A5069860841 @default.
- W1996714360 creator A5075680066 @default.
- W1996714360 creator A5084718166 @default.
- W1996714360 date "1984-11-01" @default.
- W1996714360 modified "2023-09-27" @default.
- W1996714360 title "Modification by dexamethasone of radiation response of in vitro cultured cells" @default.
- W1996714360 cites W148719451 @default.
- W1996714360 cites W1969722503 @default.
- W1996714360 cites W1996930825 @default.
- W1996714360 cites W1998530991 @default.
- W1996714360 cites W2011279571 @default.
- W1996714360 cites W2012876493 @default.
- W1996714360 cites W2027171321 @default.
- W1996714360 cites W2103885797 @default.
- W1996714360 cites W2104051837 @default.
- W1996714360 cites W4243964059 @default.
- W1996714360 doi "https://doi.org/10.1016/0360-3016(84)90210-4" @default.
- W1996714360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6490436" @default.
- W1996714360 hasPublicationYear "1984" @default.
- W1996714360 type Work @default.
- W1996714360 sameAs 1996714360 @default.
- W1996714360 citedByCount "12" @default.
- W1996714360 countsByYear W19967143602021 @default.
- W1996714360 countsByYear W19967143602022 @default.
- W1996714360 crossrefType "journal-article" @default.
- W1996714360 hasAuthorship W1996714360A5011217013 @default.
- W1996714360 hasAuthorship W1996714360A5037297048 @default.
- W1996714360 hasAuthorship W1996714360A5054855052 @default.
- W1996714360 hasAuthorship W1996714360A5069860841 @default.
- W1996714360 hasAuthorship W1996714360A5075680066 @default.
- W1996714360 hasAuthorship W1996714360A5084718166 @default.
- W1996714360 hasConcept C121608353 @default.
- W1996714360 hasConcept C126322002 @default.
- W1996714360 hasConcept C1491633281 @default.
- W1996714360 hasConcept C175656101 @default.
- W1996714360 hasConcept C202751555 @default.
- W1996714360 hasConcept C203014093 @default.
- W1996714360 hasConcept C206684579 @default.
- W1996714360 hasConcept C2780401358 @default.
- W1996714360 hasConcept C2908647359 @default.
- W1996714360 hasConcept C29537977 @default.
- W1996714360 hasConcept C509974204 @default.
- W1996714360 hasConcept C54355233 @default.
- W1996714360 hasConcept C55493867 @default.
- W1996714360 hasConcept C71924100 @default.
- W1996714360 hasConcept C81885089 @default.
- W1996714360 hasConcept C86803240 @default.
- W1996714360 hasConcept C99454951 @default.
- W1996714360 hasConceptScore W1996714360C121608353 @default.
- W1996714360 hasConceptScore W1996714360C126322002 @default.
- W1996714360 hasConceptScore W1996714360C1491633281 @default.
- W1996714360 hasConceptScore W1996714360C175656101 @default.
- W1996714360 hasConceptScore W1996714360C202751555 @default.
- W1996714360 hasConceptScore W1996714360C203014093 @default.
- W1996714360 hasConceptScore W1996714360C206684579 @default.
- W1996714360 hasConceptScore W1996714360C2780401358 @default.
- W1996714360 hasConceptScore W1996714360C2908647359 @default.
- W1996714360 hasConceptScore W1996714360C29537977 @default.
- W1996714360 hasConceptScore W1996714360C509974204 @default.
- W1996714360 hasConceptScore W1996714360C54355233 @default.
- W1996714360 hasConceptScore W1996714360C55493867 @default.
- W1996714360 hasConceptScore W1996714360C71924100 @default.
- W1996714360 hasConceptScore W1996714360C81885089 @default.
- W1996714360 hasConceptScore W1996714360C86803240 @default.
- W1996714360 hasConceptScore W1996714360C99454951 @default.
- W1996714360 hasIssue "11" @default.
- W1996714360 hasLocation W19967143601 @default.
- W1996714360 hasLocation W19967143602 @default.
- W1996714360 hasOpenAccess W1996714360 @default.
- W1996714360 hasPrimaryLocation W19967143601 @default.
- W1996714360 hasRelatedWork W1976810488 @default.
- W1996714360 hasRelatedWork W2066519212 @default.
- W1996714360 hasRelatedWork W2147582324 @default.
- W1996714360 hasRelatedWork W2358958582 @default.
- W1996714360 hasRelatedWork W2360601008 @default.
- W1996714360 hasRelatedWork W2361676139 @default.
- W1996714360 hasRelatedWork W2374840878 @default.
- W1996714360 hasRelatedWork W2409134845 @default.
- W1996714360 hasRelatedWork W2415398623 @default.
- W1996714360 hasRelatedWork W3029739001 @default.
- W1996714360 hasVolume "10" @default.
- W1996714360 isParatext "false" @default.
- W1996714360 isRetracted "false" @default.
- W1996714360 magId "1996714360" @default.
- W1996714360 workType "article" @default.