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- W1996740762 abstract "RNA tumor viruses as classified in Retroviruses have been isolated and identified to induce tumors in a variety of animals including chickens, mice, and rats, or even in human in the last 100 years, since the first one has been reported in 1908. The RNA tumor viruses have been historically classified into two groups, acute transforming RNA tumor viruses and nonacute RNA tumor viruses. Acute transforming RNA tumor viruses are basically replication-defective and rapidly induce tumors by expressing the viral oncogenes captured from cellular genome in host cells. The first oncogene derived from Rous sarcoma virus was the src non-receptor tyrosine kinase, which has been identified to play the significant roles for signal transduction. On the other hand, nonacute RNA tumor viruses, which consist of only gag, pro, pol, and env regions but do not carry oncogenes, are replication-competent and could activate the cellular proto-oncogenes by inserting the viral long terminal repeat close to the proto-oncogenes to induce tumors with a long incubation period, as is termed a promoter insertion. These molecular mechanisms have been thought to induce tumors. However, very recently several reports have described that the retroviral structural protein Envelope could directly induce tumors in vivo and transform cells in vitro. These are very unusual examples of native retroviral structural proteins with transformation potential. In this review we look back over the history of oncogenic retrovirus research and summarize recent progress for our understanding of the molecular mechanisms of oncogenic transformation by retrovirus Envelope proteins." @default.
- W1996740762 created "2016-06-24" @default.
- W1996740762 creator A5038238652 @default.
- W1996740762 creator A5079931764 @default.
- W1996740762 date "2007-01-01" @default.
- W1996740762 modified "2023-10-05" @default.
- W1996740762 title "New molecular mechanisms of virus-mediated carcinogenesis: oncogenic transformation of cells by retroviral structural protein Envelope" @default.
- W1996740762 cites W104460078 @default.
- W1996740762 cites W1502579708 @default.
- W1996740762 cites W1855068291 @default.
- W1996740762 cites W1876294625 @default.
- W1996740762 cites W1964700098 @default.
- W1996740762 cites W1967969635 @default.
- W1996740762 cites W1977100019 @default.
- W1996740762 cites W1980310885 @default.
- W1996740762 cites W1981744882 @default.
- W1996740762 cites W1987600685 @default.
- W1996740762 cites W1996071244 @default.
- W1996740762 cites W1996093792 @default.
- W1996740762 cites W1997624076 @default.
- W1996740762 cites W1998976463 @default.
- W1996740762 cites W1999888153 @default.
- W1996740762 cites W2000425457 @default.
- W1996740762 cites W2004771750 @default.
- W1996740762 cites W2005634497 @default.
- W1996740762 cites W2006982410 @default.
- W1996740762 cites W201050536 @default.
- W1996740762 cites W2013241878 @default.
- W1996740762 cites W2018638291 @default.
- W1996740762 cites W2019135795 @default.
- W1996740762 cites W2024949533 @default.
- W1996740762 cites W2026938271 @default.
- W1996740762 cites W2028519621 @default.
- W1996740762 cites W2029239823 @default.
- W1996740762 cites W2039386265 @default.
- W1996740762 cites W2045462732 @default.
- W1996740762 cites W2045712300 @default.
- W1996740762 cites W2048022927 @default.
- W1996740762 cites W2048511673 @default.
- W1996740762 cites W2048625423 @default.
- W1996740762 cites W2049686882 @default.
- W1996740762 cites W2052968919 @default.
- W1996740762 cites W2054624034 @default.
- W1996740762 cites W2058350611 @default.
- W1996740762 cites W2065897977 @default.
- W1996740762 cites W2066418230 @default.
- W1996740762 cites W2066784330 @default.
- W1996740762 cites W2067460390 @default.
- W1996740762 cites W2071794490 @default.
- W1996740762 cites W2076882149 @default.
- W1996740762 cites W2084076455 @default.
- W1996740762 cites W2086043406 @default.
- W1996740762 cites W2086080576 @default.
- W1996740762 cites W2094831592 @default.
- W1996740762 cites W2095274633 @default.
- W1996740762 cites W2096912016 @default.
- W1996740762 cites W2099809203 @default.
- W1996740762 cites W2102516824 @default.
- W1996740762 cites W2103535247 @default.
- W1996740762 cites W2103645368 @default.
- W1996740762 cites W2105392802 @default.
- W1996740762 cites W2105971413 @default.
- W1996740762 cites W2107214690 @default.
- W1996740762 cites W2108577689 @default.
- W1996740762 cites W2108832628 @default.
- W1996740762 cites W2112102302 @default.
- W1996740762 cites W2118460485 @default.
- W1996740762 cites W2122979133 @default.
- W1996740762 cites W2123679031 @default.
- W1996740762 cites W2125690438 @default.
- W1996740762 cites W2126472929 @default.
- W1996740762 cites W2129212726 @default.
- W1996740762 cites W2129923351 @default.
- W1996740762 cites W2132900300 @default.
- W1996740762 cites W2133819228 @default.
- W1996740762 cites W2137618410 @default.
- W1996740762 cites W2138534630 @default.
- W1996740762 cites W2140376837 @default.
- W1996740762 cites W2145594887 @default.
- W1996740762 cites W2148533021 @default.
- W1996740762 cites W2150602071 @default.
- W1996740762 cites W2150979387 @default.
- W1996740762 cites W2152781580 @default.
- W1996740762 cites W2157363281 @default.
- W1996740762 cites W2164270230 @default.
- W1996740762 cites W2167414186 @default.
- W1996740762 cites W2170519539 @default.
- W1996740762 cites W2171479458 @default.
- W1996740762 cites W2172255447 @default.
- W1996740762 cites W2336865896 @default.
- W1996740762 cites W2414190385 @default.
- W1996740762 cites W2480455676 @default.
- W1996740762 doi "https://doi.org/10.2222/jsv.57.159" @default.
- W1996740762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18357754" @default.
- W1996740762 hasPublicationYear "2007" @default.
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