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• W1996741741 startingPage "451" @default.
• W1996741741 abstract "Environmental exposures, including tobacco smoke and occupational exposure to aromatic amines, have been implicated in bladder cancer etiology. However, the pathogenesis of urinary bladder transitional cell carcinoma remains incompletely defined. In epidemiologic studies, family history confers a 2-fold increase in bladder cancer risk, but it is uncertain whether this represents evidence of a genetic and/or a shared environmental basis for familial aggregation. Polymorphisms in genes involved in the metabolism of environmental toxins (e.g., NAT2) clearly modify individual susceptibility to bladder cancer. A genetic predisposition has also been suggested by case reports describing multiple-case families, and the development of bladder cancer in association with several well-described Mendelian disorders (e.g., HNPCC, retinoblastoma). Here we update a previously reported family, report a new multiple-case kindred, critically review previously reported bladder cancer families, and the epidemiologic literature related to family history of transitional cell carcinoma of the urinary tract (TCCUT) as a risk factor, as well as provide a brief summary of genetic factors that have been implicated in TCCUT risk. We conclude that familial TCCUT is either very uncommon or significantly under-reported, perhaps on the assumption that this is an environmental rather than a genetic disorder. The interaction between multiple genetic and environmental factors has made it challenging to identify genetic components responsible for many common diseases; therefore, a proposed genome-wide association study (GWAS) for urinary bladder cancer may help to clarify the etiologic role of the candidate genetic pathways reviewed here, as well as characterize gene/environment interactions that contribute to TCCUT carcinogenesis." @default.
• W1996741741 created "2016-06-24" @default.
• W1996741741 creator A5019329822 @default.
• W1996741741 creator A5057976296 @default.
• W1996741741 creator A5089073198 @default.
• W1996741741 date "2008-09-01" @default.
• W1996741741 modified "2023-10-14" @default.
• W1996741741 title "Familial and genetic risk of transitional cell carcinoma of the urinary tract" @default.
• W1996741741 cites W104689066 @default.
• W1996741741 cites W136175638 @default.
• W1996741741 cites W1911995319 @default.
• W1996741741 cites W1968452508 @default.
• W1996741741 cites W1982117368 @default.
• W1996741741 cites W1984842482 @default.
• W1996741741 cites W1986084374 @default.
• W1996741741 cites W1988629478 @default.
• W1996741741 cites W1991106907 @default.
• W1996741741 cites W1996933053 @default.
• W1996741741 cites W1997828131 @default.
• W1996741741 cites W1998104932 @default.
• W1996741741 cites W2000275933 @default.
• W1996741741 cites W2001754472 @default.
• W1996741741 cites W2002276824 @default.
• W1996741741 cites W2003945237 @default.
• W1996741741 cites W2009553091 @default.
• W1996741741 cites W2013472698 @default.
• W1996741741 cites W2015212850 @default.
• W1996741741 cites W2015467663 @default.
• W1996741741 cites W2017837081 @default.
• W1996741741 cites W2018561776 @default.
• W1996741741 cites W2020743488 @default.
• W1996741741 cites W2023271413 @default.
• W1996741741 cites W2027301200 @default.
• W1996741741 cites W2029278190 @default.
• W1996741741 cites W2029562600 @default.
• W1996741741 cites W2029935530 @default.
• W1996741741 cites W2032554909 @default.
• W1996741741 cites W2035652552 @default.
• W1996741741 cites W2038963633 @default.
• W1996741741 cites W2039537494 @default.
• W1996741741 cites W2042387101 @default.
• W1996741741 cites W2044961658 @default.
• W1996741741 cites W2050375141 @default.
• W1996741741 cites W2051208811 @default.
• W1996741741 cites W2053608922 @default.
• W1996741741 cites W2058922431 @default.
• W1996741741 cites W2060196996 @default.
• W1996741741 cites W2060658196 @default.
• W1996741741 cites W2061056338 @default.
• W1996741741 cites W2061393391 @default.
• W1996741741 cites W2062533273 @default.
• W1996741741 cites W2063161883 @default.
• W1996741741 cites W2065573897 @default.
• W1996741741 cites W2066945548 @default.
• W1996741741 cites W2069064984 @default.
• W1996741741 cites W2070168194 @default.
• W1996741741 cites W2076313863 @default.
• W1996741741 cites W2080076317 @default.
• W1996741741 cites W2083325986 @default.
• W1996741741 cites W2091827806 @default.
• W1996741741 cites W2093483135 @default.
• W1996741741 cites W2094243916 @default.
• W1996741741 cites W2095677383 @default.
• W1996741741 cites W2107220005 @default.
• W1996741741 cites W2109269606 @default.
• W1996741741 cites W2116287388 @default.
• W1996741741 cites W2116774060 @default.
• W1996741741 cites W2126481021 @default.
• W1996741741 cites W2128118436 @default.
• W1996741741 cites W2128793721 @default.
• W1996741741 cites W2132931629 @default.
• W1996741741 cites W2135674762 @default.
• W1996741741 cites W2138629620 @default.
• W1996741741 cites W2139817064 @default.
• W1996741741 cites W2147502452 @default.
• W1996741741 cites W2156551891 @default.
• W1996741741 cites W2162413957 @default.
• W1996741741 cites W2163246271 @default.
• W1996741741 cites W2164157837 @default.
• W1996741741 cites W2170958906 @default.
• W1996741741 cites W2262284838 @default.
• W1996741741 cites W2291726551 @default.
• W1996741741 cites W2318367983 @default.
• W1996741741 cites W2394956224 @default.
• W1996741741 cites W2410809332 @default.
• W1996741741 cites W2411747189 @default.
• W1996741741 cites W2420472523 @default.
• W1996741741 cites W2462674826 @default.
• W1996741741 cites W49776900 @default.
• W1996741741 doi "https://doi.org/10.1016/j.urolonc.2008.02.016" @default.
• W1996741741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574230" @default.
• W1996741741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18562223" @default.
• W1996741741 hasPublicationYear "2008" @default.
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