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- W1996747347 abstract "The absorption and elimination of a single 500 mg dose of methyldopa has been studied after oral administration to 10 normal volunteers, 10 patients with coeliac disease, who were on a gluten-free diet, and to five patients with Crohn's disease. In patients with Crohn's disease the percentage of the dose recovered in urine (24%) was about one-half of normal (50%). This decreased absorption was associated with reduced plasma concentrations of both free and conjugated methyldopa and a decreased pharmacological response. In patients with coeliac disease the percentage of dose recovered in urine (43%) was similar to normals, indicating a normal absorption of the drug. However, the plasma concentrations of both free and conjugated methyldopa were significantly higher than normal, although there was no increase in drug-related effects. These findings confirm the importance of using indices other than drug plasma concentrations in the assessment of bioavailability in disease states." @default.
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- W1996747347 date "1983-07-01" @default.
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- W1996747347 title "The absorption and conjugation of methyldopa in patients with coeliac and Crohn's diseases during treatment." @default.
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- W1996747347 doi "https://doi.org/10.1111/j.1365-2125.1983.tb02147.x" @default.
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