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• W1996749457 abstract "Literary data suggest apparently ambiguous interaction between menopausal status and obesity-associated breast cancer risk based on the principle of the carcinogenic capacity of estrogen. Before menopause, breast cancer incidence is relatively low and adiposity is erroneously regarded as a protective factor against this tumor conferred by the obesity associated defective estrogen-synthesis. By contrast, in postmenopausal cases, obesity presents a strong risk factor for breast cancer being mistakenly attributed to the presumed excessive estrogen-production of their adipose-tissue mass. Obesity is associated with dysmetabolism and endangers the healthy equilibrium of sexual hormone-production and regular menstrual cycles in women, which are the prerequisites not only for reproductive capacity but also for somatic health. At the same time, literary data support that anovulatory infertility is a very strong risk for breast cancer in young women either with or without obesity. In the majority of premenopausal women, obesity associated insulin resistance is moderate and may be counteracted by their preserved circulatory estrogen level. Consequently, it is not obesity but rather the still sufficient estrogen-level, which may be protective against breast cancer in young adult females. In obese older women, never using hormone replacement therapy (HRT) the breast cancer risk is high, which is associated with their continuous estrogen loss and increasing insulin-resistance. By contrast, obese postmenopausal women using HRT, have a decreased risk for breast cancer as the protective effect of estrogen-substitution may counteract to their obesity associated systemic alterations. The revealed inverse correlation between circulatory estrogen-level and breast cancer risk in obese women should advance our understanding of breast cancer etiology and promotes primary prevention measures. New patents recommend various methods for the prevention and treatment of obesity-related systemic disorders and the associated breast cancer." @default.
• W1996749457 created "2016-06-24" @default.
• W1996749457 creator A5081986423 @default.
• W1996749457 date "2013-02-01" @default.
• W1996749457 modified "2023-09-30" @default.
• W1996749457 title "Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women" @default.
• W1996749457 cites W127895075 @default.
• W1996749457 cites W1482879066 @default.
• W1996749457 cites W1511930757 @default.
• W1996749457 cites W1519642534 @default.
• W1996749457 cites W1527764486 @default.
• W1996749457 cites W1548058762 @default.
• W1996749457 cites W1554155016 @default.
• W1996749457 cites W158665280 @default.
• W1996749457 cites W1593442063 @default.
• W1996749457 cites W1601528092 @default.
• W1996749457 cites W16253337 @default.
• W1996749457 cites W1781176060 @default.
• W1996749457 cites W1835582227 @default.
• W1996749457 cites W1941476277 @default.
• W1996749457 cites W1950443258 @default.
• W1996749457 cites W1954333522 @default.
• W1996749457 cites W1966199649 @default.
• W1996749457 cites W1967486564 @default.
• W1996749457 cites W1969385945 @default.
• W1996749457 cites W1970154845 @default.
• W1996749457 cites W1970814316 @default.
• W1996749457 cites W1971047979 @default.
• W1996749457 cites W1971163824 @default.
• W1996749457 cites W1971288716 @default.
• W1996749457 cites W1974090160 @default.
• W1996749457 cites W1974401971 @default.
• W1996749457 cites W1975142697 @default.
• W1996749457 cites W1975400136 @default.
• W1996749457 cites W1975572878 @default.
• W1996749457 cites W1978583076 @default.
• W1996749457 cites W1978635385 @default.
• W1996749457 cites W1980183623 @default.
• W1996749457 cites W1981506841 @default.
• W1996749457 cites W1983901656 @default.
• W1996749457 cites W1985903716 @default.
• W1996749457 cites W1987144846 @default.
• W1996749457 cites W1988710990 @default.
• W1996749457 cites W1992609447 @default.
• W1996749457 cites W1994078451 @default.
• W1996749457 cites W1996157904 @default.
• W1996749457 cites W1997647901 @default.
• W1996749457 cites W1998926248 @default.
• W1996749457 cites W2001649722 @default.
• W1996749457 cites W2002631438 @default.
• W1996749457 cites W2002750845 @default.
• W1996749457 cites W2006014496 @default.
• W1996749457 cites W2007625194 @default.
• W1996749457 cites W2012163680 @default.
• W1996749457 cites W2012740498 @default.
• W1996749457 cites W2014046105 @default.
• W1996749457 cites W2015429374 @default.
• W1996749457 cites W2020552150 @default.
• W1996749457 cites W2020938980 @default.
• W1996749457 cites W2022041080 @default.
• W1996749457 cites W2022415850 @default.
• W1996749457 cites W2024440325 @default.
• W1996749457 cites W2031456594 @default.
• W1996749457 cites W2032020304 @default.
• W1996749457 cites W2035626737 @default.
• W1996749457 cites W2036159218 @default.
• W1996749457 cites W2036591209 @default.
• W1996749457 cites W2037440187 @default.
• W1996749457 cites W2037621705 @default.
• W1996749457 cites W2038088682 @default.
• W1996749457 cites W2038929880 @default.
• W1996749457 cites W2039043015 @default.
• W1996749457 cites W2041103503 @default.
• W1996749457 cites W2041109111 @default.
• W1996749457 cites W2041281080 @default.
• W1996749457 cites W2041551814 @default.
• W1996749457 cites W2041642374 @default.
• W1996749457 cites W2044900527 @default.
• W1996749457 cites W2045170174 @default.
• W1996749457 cites W2045305984 @default.
• W1996749457 cites W2045612703 @default.
• W1996749457 cites W2046414023 @default.
• W1996749457 cites W2046552895 @default.
• W1996749457 cites W2048376750 @default.
• W1996749457 cites W2049381105 @default.
• W1996749457 cites W2050566788 @default.
• W1996749457 cites W2050826343 @default.
• W1996749457 cites W2050847082 @default.
• W1996749457 cites W2051051060 @default.
• W1996749457 cites W2052757994 @default.
• W1996749457 cites W2053459048 @default.
• W1996749457 cites W2054276470 @default.
• W1996749457 cites W2055020295 @default.
• W1996749457 cites W2056531060 @default.
• W1996749457 cites W2057023689 @default.
• W1996749457 cites W2057273565 @default.
• W1996749457 cites W2057994246 @default.
• W1996749457 cites W2061975232 @default.

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