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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996752422> ?p ?o ?g. }

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• W1996752422 abstract "A phosphinate analog of glutathionyl spermidine (Gsp), 3, has been synthesized and evaluated as an inhibitor of Gsp synthetase (GSPS). In addition, a non-spermidine-containing derivative (4) was synthesized in order to evaluate the role of the polyamine moiety in ligand binding. Compound 4 showed almost no inhibitory activity against E. coli GSPS while 3 was found to be a potent, slow-binding inhibitor of this enzyme, with the collisional E·I complex isomerizing to an E·I∗ complex with 410-fold higher affinity." @default.
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• W1996752422 date "1997-03-01" @default.
• W1996752422 modified "2023-10-10" @default.
• W1996752422 title "Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase" @default.
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• W1996752422 doi "https://doi.org/10.1016/s0960-894x(97)00061-9" @default.
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