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• W1996757777 abstract "I agreed to enter a debate siding against the value of indium-111 (111In)-capromab pendetide (Cyt-356) (ProstaScint) imaging with mixed emotions. On the one hand, our group has been involved with the development and application of radioimmune localization (RIL) for many years both experimentally and clinically. 1 Chiou R.K. Vessella R.L. Elson M.K. et al. Localization of human renal cell carcinoma xenografts with a tumor preferential monoclonal antibody. Cancer Res. 1985; 45: 6140-6416 Google Scholar , 2 Palme D.F. Berkopec J.M. Elson M.K. et al. Dosimetry and pharmacokinetics of monoclonal antibody A6H with human renal cell carcinoma xenografts single dose study. Nucl Med Biol. 1991; 18: 527-537 Google Scholar , 3 Vessella R.L. Alvarez V. Chiou R.K. et al. Radioimmunoscintigraphy and radioimmunotherapy of renal cell carcinoma xenografts. Cancer Treatment Symposia, NCI Monogr. 1987; 3: 159-167 Google Scholar , 4 Vessella RL: Radioimmunoconjugates in renal cell carcinoma, in Debruyne FMJ, Bukowski RM, Pontes JE, et al (Eds): Immunotherapy of Renal Cell Carcinoma. Heidelberg, Springer-Verlag, 1991, pp 38–46. Google Scholar , 5 Wilbur D.S. Pathare P.M. Hamlin D.K. et al. Biotin reagents for antibody pretargeting. 3. Synthesis, radioiodination and evaluation of biotinylated starburst dendrimers. Bioconjugate Chemistry. 1998; 9: 813-825 Crossref Scopus (108) Google Scholar , 6 Vessella RL, Wilbur DS, Buhler K, et al: Experimental models and methods in antibody targeting of renal cell carcinoma, in Mydlo J (Ed): Renal Cancer: Methods and Protocol, as part of Walker J (Ed): Methods in Molecular Medicine. Totowa, Humana Press, 2000. Google Scholar Also, I have had clinical experience with many industry-sponsored urology applications targeting carcinoembryonic antigen, alpha-fetoprotein, and prostate-specific antigen (PSA) over the years. Indeed, I very enthusiastically participated in 111In-Cyt-356 imaging clinical studies 7 Manyak M.J. Hinkle G.H. Olsen J.O. et al. Immunoscintigraphy with indium-111-capromab pendetide evaluation before definitive therapy in patients with prostate cancer. Urology. 1999; 54: 1058-1063 Abstract Full Text Full Text PDF PubMed Google Scholar and was glad when the test was approved for clinical use. We have performed more than 100 111In-Cyt-356 scans at our institution and continue to perform them in selected cases. On the other hand, that very long experience, together with the documented mixed results of clinical RIL in many other cancers, 8 Sands H. Experimental studies of radioimmunodetection of cancer an overview. Cancer Res. 1990; 50: 809-813 Google Scholar , 9 Zuckier L.S. DeNardo G.L. Trials and tribulations oncological antibody imaging comes to the fore. Semin Nucl Med. 1997; 27: 10-29 Abstract Full Text PDF PubMed Scopus (59) Google Scholar , 10 Moffat Jr, F.L. Gulec S.A. Serafini A.N. et al. A thousand points of light or just dim bulbs? Radiolabeled antibodies and colorectal cancer imaging. Cancer Invest. 1999; 17: 322-334 Crossref Scopus (26) Google Scholar has given me a level of skepticism that, I hope, will be constructive to this debate. I desperately want to believe in the clinical utility of 111In-Cyt-356 scanning, but I do not want to be disappointed again." @default.
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• W1996757777 title "ProstaScint scan for staging prostate cancer" @default.
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