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- W1996760931 abstract "From the authors: We thank S.P. Tofovic and E.K. Jackson for their interest in our study [1]. It is well known that pulmonary arterial hypertension (PAH) is a female-predominant disease [2–4], and this seems to indicate that oestrogens may be predisposing factors. However, this contrasts with the fact that females with PAH have preserved right ventricle function and survival compared with males with PAH [2–5], suggesting that oestrogens could be protective of PAH. So, oestrogens may be viewed as a double-edged sword in PAH. To explore the role of oestrogens in PAH, we observed the effect of endogenous and exogenous E2 (17β-oestradiol) in rats with monocrotaline (MCT)-induced pulmonary hypertension (PH) [1]. Our results suggested similar protective roles of endogenous and exogenous E2 in pulmonary vascular remodelling and right ventricular hypertrophy in MCT-induced PH rats, which is similar to the …" @default.
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- W1996760931 date "2013-05-31" @default.
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- W1996760931 title "Complexities of oestradiol pharmacology in pulmonary arterial hypertension" @default.
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- W1996760931 doi "https://doi.org/10.1183/09031936.00176212" @default.
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