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- W1996761750 abstract "Previously we have shown that atrial natriuretic peptide (ANP) has anxiolytic-like properties after intraperitoneal, intracerebroventricular and intraamygdala infusion in rats. Since C-type natriuretic peptide (CNP) exerts endocrine and behavioral effects opposing those of ANP, we characterized the behavioral properties of CNP after icv infusion in rats by their performance in the elevated plus maze with and without the corticotropin-releasing hormone (CRH) antagonist α-helical-CRH (α-CRH). Low CNP doses of 0.05 μg icv or 0.1 μg icv did not significantly influence the behavior of rats in the plus maze. At higher doses (0.5 μg, 2 μg, 5 μg icv) CNP had distinct anxiogenic properties. Our hypothesis that corticotropin-releasing hormone (CRH) is involved, which elicits anxiety-like behavior, was examined by icv coadministration of α-CRH, an antagonist at CRH-1 and CRH-2-receptors. Icv α-CRH alone had no intrinsic anxiolytic properties at a dose of 25 μg. The anxiogenic effects of 2 μg CNP icv seen in the plus maze were entirely blocked by α-CRH. Directly after exposition ACTH and corticosterone levels did not differ between the groups, but after 30 min ACTH levels were significantly higher in the CNP-treated group compared to α-CRH/CNP-treated animals. Corticosterone was found significantly lowered in the α-CRH/saline group compared to the CNP treated group but not compared to saline controls. Our data suggest opposing effects of CNP and ANP on anxiety-related behavior and neuroendocrine regulation in rats, which appear to be mediated via different receptor occupation and brain regions, and by a CRH-dependent mechanism." @default.
- W1996761750 created "2016-06-24" @default.
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- W1996761750 date "2001-03-01" @default.
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- W1996761750 title "α-Helical-corticotropin-releasing hormone reverses anxiogenic effects of C-type natriuretic peptide in rats" @default.
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- W1996761750 doi "https://doi.org/10.1016/s0006-8993(00)03275-3" @default.
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