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• W1996762358 abstract "Single-stranded telomeric DNA tends to fold into G-quadruplexes made of a stack of G-quartets. Ligands that target G-quadruplex DNA have received considerable attention because of their potential anticancer activity. In this paper, we designed a fluorescence resonance energy transfer system to identify drugs that form G-quadruplexes with human telomeric DNA in a homogeneous medium using gold nanorods (GNRs) as fluorescence quencher. Fluorescein-tagged human telomeric DNA (F-GDNA) adsorbed on the surface of GNRs, which can quench the fluorescence of F-GDNA. In the presence of G-quadruplex-binding drugs, the formation of G-quadruplex further quenched the fluorescence of F-GDNA, which can be utilized to select G-quadruplex-binding ligands. Thirteen natural drugs were studied by this proposed method. G-quadruplex formation induced by drugs was investigated by circular dichroism measurements. Results of research indicated that it offers a simple, sensitive and effective method to identify ligands with potential anticancer activity." @default.
• W1996762358 created "2016-06-24" @default.
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• W1996762358 date "2011-07-23" @default.
• W1996762358 modified "2023-10-13" @default.
• W1996762358 title "Gold nanorod-based FRET assay for selection of G-quadruplex-binding ligands" @default.
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• W1996762358 doi "https://doi.org/10.1007/s13404-011-0022-9" @default.
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