FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996764552> ?p ?o ?g. }

• W1996764552 endingPage "76.e24" @default.
• W1996764552 startingPage "76.e15" @default.
• W1996764552 abstract "Objective Endogenous uterine agonists can activate numerous signaling pathways to effect increased force. Our objective was to assess expression of key constituents of these pathways, in alliance with contractile function, through late gestation and during term and preterm labor. Study Design Using myography, we measured the response to 3 agonists compared with depolarization alone (K+, 124 mEq/L) and calculated agonist/depolarization ratio. We measured gene expression using quantitative reverse transcription–polymerase chain reaction. Results Contractile responsiveness to depolarization alone, oxytocin, or endothelin-1 increased during pregnancy compared with nonpregnant animals. The agonist/depolarization ratio did not change during uterine activation or parturition. Inhibition of rhoA-associated kinase decreased responses to oxytocin in all tissues, but significantly more during uterine activation. Expression of rhoA and rhoA-associated kinase was increased significantly in active labor at term or preterm. Conclusion The rhoA/rhoA-associated kinase pathway is a key regulator of uterine activation during labor and may be a useful target for the prevention of spontaneous preterm birth. Endogenous uterine agonists can activate numerous signaling pathways to effect increased force. Our objective was to assess expression of key constituents of these pathways, in alliance with contractile function, through late gestation and during term and preterm labor. Using myography, we measured the response to 3 agonists compared with depolarization alone (K+, 124 mEq/L) and calculated agonist/depolarization ratio. We measured gene expression using quantitative reverse transcription–polymerase chain reaction. Contractile responsiveness to depolarization alone, oxytocin, or endothelin-1 increased during pregnancy compared with nonpregnant animals. The agonist/depolarization ratio did not change during uterine activation or parturition. Inhibition of rhoA-associated kinase decreased responses to oxytocin in all tissues, but significantly more during uterine activation. Expression of rhoA and rhoA-associated kinase was increased significantly in active labor at term or preterm. The rhoA/rhoA-associated kinase pathway is a key regulator of uterine activation during labor and may be a useful target for the prevention of spontaneous preterm birth." @default.
• W1996764552 created "2016-06-24" @default.
• W1996764552 creator A5038442760 @default.
• W1996764552 creator A5040827044 @default.
• W1996764552 creator A5050974711 @default.
• W1996764552 creator A5089488452 @default.
• W1996764552 date "2012-07-01" @default.
• W1996764552 modified "2023-10-03" @default.
• W1996764552 title "Molecular pathways regulating contractility in rat uterus through late gestation and parturition" @default.
• W1996764552 cites W1507228972 @default.
• W1996764552 cites W1512437302 @default.
• W1996764552 cites W1597258706 @default.
• W1996764552 cites W1676765468 @default.
• W1996764552 cites W1857294168 @default.
• W1996764552 cites W1979466229 @default.
• W1996764552 cites W1980166477 @default.
• W1996764552 cites W1990940102 @default.
• W1996764552 cites W1991032022 @default.
• W1996764552 cites W1999052792 @default.
• W1996764552 cites W2001831042 @default.
• W1996764552 cites W2007009112 @default.
• W1996764552 cites W2014234136 @default.
• W1996764552 cites W2022185889 @default.
• W1996764552 cites W2028822365 @default.
• W1996764552 cites W2029199426 @default.
• W1996764552 cites W2034375622 @default.
• W1996764552 cites W2034790817 @default.
• W1996764552 cites W2037067429 @default.
• W1996764552 cites W2037116295 @default.
• W1996764552 cites W2047482446 @default.
• W1996764552 cites W2051892081 @default.
• W1996764552 cites W2073947893 @default.
• W1996764552 cites W2088900491 @default.
• W1996764552 cites W2092358876 @default.
• W1996764552 cites W2093507069 @default.
• W1996764552 cites W2108244474 @default.
• W1996764552 cites W2113974411 @default.
• W1996764552 cites W2118806690 @default.
• W1996764552 cites W2120721252 @default.
• W1996764552 cites W2125836586 @default.
• W1996764552 cites W2136807024 @default.
• W1996764552 cites W2138742704 @default.
• W1996764552 cites W2144783911 @default.
• W1996764552 cites W2150647707 @default.
• W1996764552 cites W2152731776 @default.
• W1996764552 cites W2157743441 @default.
• W1996764552 cites W2158895430 @default.
• W1996764552 cites W2161352629 @default.
• W1996764552 cites W2162101429 @default.
• W1996764552 cites W2254098459 @default.
• W1996764552 doi "https://doi.org/10.1016/j.ajog.2012.04.036" @default.
• W1996764552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22727353" @default.
• W1996764552 hasPublicationYear "2012" @default.
• W1996764552 type Work @default.
• W1996764552 sameAs 1996764552 @default.
• W1996764552 citedByCount "14" @default.
• W1996764552 countsByYear W19967645522012 @default.
• W1996764552 countsByYear W19967645522013 @default.
• W1996764552 countsByYear W19967645522017 @default.
• W1996764552 countsByYear W19967645522018 @default.
• W1996764552 countsByYear W19967645522019 @default.
• W1996764552 countsByYear W19967645522021 @default.
• W1996764552 countsByYear W19967645522023 @default.
• W1996764552 crossrefType "journal-article" @default.
• W1996764552 hasAuthorship W1996764552A5038442760 @default.
• W1996764552 hasAuthorship W1996764552A5040827044 @default.
• W1996764552 hasAuthorship W1996764552A5050974711 @default.
• W1996764552 hasAuthorship W1996764552A5089488452 @default.
• W1996764552 hasConcept C126322002 @default.
• W1996764552 hasConcept C134018914 @default.
• W1996764552 hasConcept C149601957 @default.
• W1996764552 hasConcept C170493617 @default.
• W1996764552 hasConcept C181612422 @default.
• W1996764552 hasConcept C2776176026 @default.
• W1996764552 hasConcept C2776766599 @default.
• W1996764552 hasConcept C2777093181 @default.
• W1996764552 hasConcept C2778938600 @default.
• W1996764552 hasConcept C2779066055 @default.
• W1996764552 hasConcept C39133596 @default.
• W1996764552 hasConcept C4141045 @default.
• W1996764552 hasConcept C62478195 @default.
• W1996764552 hasConcept C71924100 @default.
• W1996764552 hasConcept C86803240 @default.
• W1996764552 hasConcept C95444343 @default.
• W1996764552 hasConceptScore W1996764552C126322002 @default.
• W1996764552 hasConceptScore W1996764552C134018914 @default.
• W1996764552 hasConceptScore W1996764552C149601957 @default.
• W1996764552 hasConceptScore W1996764552C170493617 @default.
• W1996764552 hasConceptScore W1996764552C181612422 @default.
• W1996764552 hasConceptScore W1996764552C2776176026 @default.
• W1996764552 hasConceptScore W1996764552C2776766599 @default.
• W1996764552 hasConceptScore W1996764552C2777093181 @default.
• W1996764552 hasConceptScore W1996764552C2778938600 @default.
• W1996764552 hasConceptScore W1996764552C2779066055 @default.
• W1996764552 hasConceptScore W1996764552C39133596 @default.
• W1996764552 hasConceptScore W1996764552C4141045 @default.
• W1996764552 hasConceptScore W1996764552C62478195 @default.
• W1996764552 hasConceptScore W1996764552C71924100 @default.

• next