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- W1996765638 abstract "The ongoing scourge of malaria, currently claiming over 2 million lives in Africa and Asia, is compounded by the growing resistance of the principle form of the disease, Plasmodium falciparum, to chloroquine (CQ) and other antimalarials. CQ, an inexpensive quinine-derived drug, has been employed for over 40 years, but is largely no longer useful. There is an urgent need for new antimalarials which are both effective against the new strains of drug-resistant P. falciparum, but also affordable by the people in most need. Toward this goal, we have synthesized many analogues to explore the activity against CQ-resistant P. falciparum. In this work, we present a quantitative structure-activity analysis of 108 CQ analogues to further explore the relationship between chemical structure and biological activity." @default.
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- W1996765638 date "2008-02-01" @default.
- W1996765638 modified "2023-09-25" @default.
- W1996765638 title "Quantitative Structure-Activity Relationships of Potential Antimalarial Drugs Active Against Chloroquine-Resistant Plasmodium Falciparum" @default.
- W1996765638 doi "https://doi.org/10.1055/s-2008-1075144" @default.
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