FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996768240> ?p ?o ?g. }

• W1996768240 endingPage "1232" @default.
• W1996768240 startingPage "1229" @default.
• W1996768240 abstract "Three electrophilic homologous aminoalkylaziridine analogues of putrescine, cadaverine, and 1,3-diaminopropane were synthesized and found to represent a mechanistically distinct class of irreversible inhibitors of diamine oxidase. The putrescine analogue, N -(4-aminobutyl)aziridine gave the lowest calculated IC 50 value, whereas N -(3-aminopropyl)aziridine, an analogue of the poorest substrate of the series, showed the highest IC 50 . The findings suggest that the aziridinylalkylamines tested are site-directed agents that form irreversible complexes at the active site of diamine oxidase. Affinity of the inhibitors for the active site appeared to be dependent on alkyl chain length, suggesting that binding promotes the reactivity of the aziridinyl group." @default.
• W1996768240 created "2016-06-24" @default.
• W1996768240 creator A5031767581 @default.
• W1996768240 creator A5036744586 @default.
• W1996768240 creator A5090853059 @default.
• W1996768240 date "1992-09-01" @default.
• W1996768240 modified "2023-09-23" @default.
• W1996768240 title "Active-site directed irreversible inhibition of diamine oxidase by a homologous series of aziridinylalkylamines" @default.
• W1996768240 cites W1498102961 @default.
• W1996768240 cites W1580202025 @default.
• W1996768240 cites W1606130875 @default.
• W1996768240 cites W1813169777 @default.
• W1996768240 cites W1829505041 @default.
• W1996768240 cites W1964758010 @default.
• W1996768240 cites W1971588717 @default.
• W1996768240 cites W1983435230 @default.
• W1996768240 cites W1985860736 @default.
• W1996768240 cites W1992840251 @default.
• W1996768240 cites W2000144464 @default.
• W1996768240 cites W2016493794 @default.
• W1996768240 cites W2017720136 @default.
• W1996768240 cites W2032223090 @default.
• W1996768240 cites W2037156112 @default.
• W1996768240 cites W2037315379 @default.
• W1996768240 cites W2049207619 @default.
• W1996768240 cites W2060116740 @default.
• W1996768240 cites W2060430211 @default.
• W1996768240 cites W2069941361 @default.
• W1996768240 cites W2071182605 @default.
• W1996768240 cites W2077945404 @default.
• W1996768240 cites W2082629145 @default.
• W1996768240 cites W2315082963 @default.
• W1996768240 cites W2331151526 @default.
• W1996768240 cites W2473614247 @default.
• W1996768240 cites W312293387 @default.
• W1996768240 cites W4214573746 @default.
• W1996768240 cites W1983934969 @default.
• W1996768240 doi "https://doi.org/10.1016/0006-2952(92)90392-v" @default.
• W1996768240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1417947" @default.
• W1996768240 hasPublicationYear "1992" @default.
• W1996768240 type Work @default.
• W1996768240 sameAs 1996768240 @default.
• W1996768240 citedByCount "5" @default.
• W1996768240 crossrefType "journal-article" @default.
• W1996768240 hasAuthorship W1996768240A5031767581 @default.
• W1996768240 hasAuthorship W1996768240A5036744586 @default.
• W1996768240 hasAuthorship W1996768240A5090853059 @default.
• W1996768240 hasConcept C107824862 @default.
• W1996768240 hasConcept C161790260 @default.
• W1996768240 hasConcept C178790620 @default.
• W1996768240 hasConcept C181199279 @default.
• W1996768240 hasConcept C185592680 @default.
• W1996768240 hasConcept C18903297 @default.
• W1996768240 hasConcept C2776016237 @default.
• W1996768240 hasConcept C2776482079 @default.
• W1996768240 hasConcept C2776928777 @default.
• W1996768240 hasConcept C2777167505 @default.
• W1996768240 hasConcept C2777289219 @default.
• W1996768240 hasConcept C2778544067 @default.
• W1996768240 hasConcept C2779053737 @default.
• W1996768240 hasConcept C2780263894 @default.
• W1996768240 hasConcept C2780378348 @default.
• W1996768240 hasConcept C2780871995 @default.
• W1996768240 hasConcept C41183919 @default.
• W1996768240 hasConcept C50027330 @default.
• W1996768240 hasConcept C515207424 @default.
• W1996768240 hasConcept C55493867 @default.
• W1996768240 hasConcept C71240020 @default.
• W1996768240 hasConcept C86803240 @default.
• W1996768240 hasConceptScore W1996768240C107824862 @default.
• W1996768240 hasConceptScore W1996768240C161790260 @default.
• W1996768240 hasConceptScore W1996768240C178790620 @default.
• W1996768240 hasConceptScore W1996768240C181199279 @default.
• W1996768240 hasConceptScore W1996768240C185592680 @default.
• W1996768240 hasConceptScore W1996768240C18903297 @default.
• W1996768240 hasConceptScore W1996768240C2776016237 @default.
• W1996768240 hasConceptScore W1996768240C2776482079 @default.
• W1996768240 hasConceptScore W1996768240C2776928777 @default.
• W1996768240 hasConceptScore W1996768240C2777167505 @default.
• W1996768240 hasConceptScore W1996768240C2777289219 @default.
• W1996768240 hasConceptScore W1996768240C2778544067 @default.
• W1996768240 hasConceptScore W1996768240C2779053737 @default.
• W1996768240 hasConceptScore W1996768240C2780263894 @default.
• W1996768240 hasConceptScore W1996768240C2780378348 @default.
• W1996768240 hasConceptScore W1996768240C2780871995 @default.
• W1996768240 hasConceptScore W1996768240C41183919 @default.
• W1996768240 hasConceptScore W1996768240C50027330 @default.
• W1996768240 hasConceptScore W1996768240C515207424 @default.
• W1996768240 hasConceptScore W1996768240C55493867 @default.
• W1996768240 hasConceptScore W1996768240C71240020 @default.
• W1996768240 hasConceptScore W1996768240C86803240 @default.
• W1996768240 hasIssue "6" @default.
• W1996768240 hasLocation W19967682401 @default.
• W1996768240 hasLocation W19967682402 @default.
• W1996768240 hasOpenAccess W1996768240 @default.
• W1996768240 hasPrimaryLocation W19967682401 @default.
• W1996768240 hasRelatedWork W1544790606 @default.
• W1996768240 hasRelatedWork W1983902209 @default.

• next