Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996773341> ?p ?o ?g. }
- W1996773341 abstract "Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads. It is present in the extracellular matrix in the form of proteoglycan aggregates, in which many aggrecan molecules interact with hyaluronan and a link protein stabilizes each interaction. Aggrecan structure is not constant throughout life, but changes due to both synthetic and degradative events. Changes due to synthesis alter the structure of the chondroitin sulfate and keratan sulfate chains, whereas those due to degradation cause cleavage of all components of the aggregate. These latter changes can be viewed as being detrimental to cartilage function and are enhanced in osteoarthritic cartilage, resulting in aggrecan depletion and predisposing to cartilage erosion. Matrix metalloproteinases and aggrecanases play a major role in aggrecan degradation and their production is upregulated by mediators associated with joint inflammation and overloading. The presence of increased levels of aggrecan fragments in synovial fluid has been used as a marker of ongoing cartilage destruction in osteoarthritis. During the early stages of osteoarthritis it may be possible to retard the destructive process by enhancing the production of aggrecan and inhibiting its degradation. Aggrecan production also plays a central role in cartilage repair techniques involving stem cell or chondrocyte implantation into lesions. Thus aggrecan participates in both the demise and survival of articular cartilage." @default.
- W1996773341 created "2016-06-24" @default.
- W1996773341 creator A5002527454 @default.
- W1996773341 creator A5085462956 @default.
- W1996773341 date "2014-07-16" @default.
- W1996773341 modified "2023-10-11" @default.
- W1996773341 title "The role of aggrecan in normal and osteoarthritic cartilage" @default.
- W1996773341 cites W121777809 @default.
- W1996773341 cites W1272499475 @default.
- W1996773341 cites W1481125168 @default.
- W1996773341 cites W1486203466 @default.
- W1996773341 cites W1494656326 @default.
- W1996773341 cites W1495512922 @default.
- W1996773341 cites W1510794293 @default.
- W1996773341 cites W1550771087 @default.
- W1996773341 cites W1564232667 @default.
- W1996773341 cites W1564532449 @default.
- W1996773341 cites W1571924012 @default.
- W1996773341 cites W1588094592 @default.
- W1996773341 cites W1615883506 @default.
- W1996773341 cites W1712774648 @default.
- W1996773341 cites W1719748145 @default.
- W1996773341 cites W1779148953 @default.
- W1996773341 cites W1814598185 @default.
- W1996773341 cites W1860225490 @default.
- W1996773341 cites W1964802599 @default.
- W1996773341 cites W1964838687 @default.
- W1996773341 cites W1973204863 @default.
- W1996773341 cites W1977063541 @default.
- W1996773341 cites W1979723337 @default.
- W1996773341 cites W1980911592 @default.
- W1996773341 cites W1986198423 @default.
- W1996773341 cites W1986524469 @default.
- W1996773341 cites W1987415652 @default.
- W1996773341 cites W1987873042 @default.
- W1996773341 cites W1993962364 @default.
- W1996773341 cites W2006613142 @default.
- W1996773341 cites W2007912953 @default.
- W1996773341 cites W2009393104 @default.
- W1996773341 cites W2010326838 @default.
- W1996773341 cites W2010404343 @default.
- W1996773341 cites W2023340898 @default.
- W1996773341 cites W2023702933 @default.
- W1996773341 cites W2024893641 @default.
- W1996773341 cites W2030453203 @default.
- W1996773341 cites W2032255522 @default.
- W1996773341 cites W2033123991 @default.
- W1996773341 cites W2033144368 @default.
- W1996773341 cites W2034725696 @default.
- W1996773341 cites W2034919108 @default.
- W1996773341 cites W2039577700 @default.
- W1996773341 cites W2044441423 @default.
- W1996773341 cites W2044757260 @default.
- W1996773341 cites W2045731972 @default.
- W1996773341 cites W2045973674 @default.
- W1996773341 cites W2047744931 @default.
- W1996773341 cites W2049568701 @default.
- W1996773341 cites W2051102442 @default.
- W1996773341 cites W2055331835 @default.
- W1996773341 cites W2057491978 @default.
- W1996773341 cites W2065039443 @default.
- W1996773341 cites W2065895195 @default.
- W1996773341 cites W2071948888 @default.
- W1996773341 cites W2075322357 @default.
- W1996773341 cites W2078397279 @default.
- W1996773341 cites W2080270214 @default.
- W1996773341 cites W2081274618 @default.
- W1996773341 cites W2081870187 @default.
- W1996773341 cites W2085439659 @default.
- W1996773341 cites W2085892676 @default.
- W1996773341 cites W2086195002 @default.
- W1996773341 cites W2086913650 @default.
- W1996773341 cites W2088633520 @default.
- W1996773341 cites W2090556419 @default.
- W1996773341 cites W2091800185 @default.
- W1996773341 cites W2094942887 @default.
- W1996773341 cites W2096464236 @default.
- W1996773341 cites W2104913975 @default.
- W1996773341 cites W2104977036 @default.
- W1996773341 cites W2106862840 @default.
- W1996773341 cites W2108434819 @default.
- W1996773341 cites W2114769400 @default.
- W1996773341 cites W2118259889 @default.
- W1996773341 cites W2122751744 @default.
- W1996773341 cites W2123158441 @default.
- W1996773341 cites W2130561093 @default.
- W1996773341 cites W2134979259 @default.
- W1996773341 cites W2136314808 @default.
- W1996773341 cites W2139966914 @default.
- W1996773341 cites W2144058774 @default.
- W1996773341 cites W2151451049 @default.
- W1996773341 cites W2167704983 @default.
- W1996773341 cites W2210166980 @default.
- W1996773341 cites W2301002461 @default.
- W1996773341 cites W2301452855 @default.
- W1996773341 cites W2331309753 @default.
- W1996773341 cites W2341720846 @default.
- W1996773341 cites W2409337244 @default.
- W1996773341 cites W2467949190 @default.
- W1996773341 cites W4230631335 @default.