Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996779897> ?p ?o ?g. }
- W1996779897 endingPage "18" @default.
- W1996779897 startingPage "1" @default.
- W1996779897 abstract "NBM-T-L-BMX-OS01 (BMX) was derived from the semisynthesis of osthole, isolated from Cnidium monnieri (L.) Cuss., and was identified to be a potent inhibitor of HDAC8. This study shows that HDAC8 is highly expressed in the pancreas and the brain. The function of HDAC8 in the brain has not been adequately studied. Because BMX enhances neurite outgrowth and cAMP response element-binding protein (CREB) activation, the effect of BMX on neural plasticity such as learning and memory is examined. To examine declarative and nondeclarative memory, a water maze, a passive one-way avoidance task, and a novel object recognition task were performed. Results from the water maze revealed that BMX and suberoylanilide-hydroxamic-acid-(SAHA-) treated rats showed shorter escape latency in finding the hidden platform. The BMX-treated animals spent more time in the target quadrant in the probe trial performance. An analysis of the passive one-way avoidance results showed that the BMX-treated animals stayed longer in the illuminated chamber by 1 day and 7 days after footshock. The novel object recognition task revealed that the BMX-treated animals showed a marked increase in the time spent exploring novel objects. Furthermore, BMX ameliorates scopolamine-(Sco-) induced learning and memory impairment in animals, indicating a novel role of BMX in learning and memory." @default.
- W1996779897 created "2016-06-24" @default.
- W1996779897 creator A5001081386 @default.
- W1996779897 creator A5003646781 @default.
- W1996779897 creator A5012615787 @default.
- W1996779897 creator A5013341045 @default.
- W1996779897 creator A5028962524 @default.
- W1996779897 creator A5045347986 @default.
- W1996779897 creator A5050156265 @default.
- W1996779897 creator A5078963995 @default.
- W1996779897 creator A5087000397 @default.
- W1996779897 date "2013-01-01" @default.
- W1996779897 modified "2023-10-04" @default.
- W1996779897 title "NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats" @default.
- W1996779897 cites W1964372470 @default.
- W1996779897 cites W1967061503 @default.
- W1996779897 cites W1970800800 @default.
- W1996779897 cites W1974684927 @default.
- W1996779897 cites W1982162410 @default.
- W1996779897 cites W1987381637 @default.
- W1996779897 cites W1996151441 @default.
- W1996779897 cites W2000048200 @default.
- W1996779897 cites W2006234471 @default.
- W1996779897 cites W2006932820 @default.
- W1996779897 cites W2008650297 @default.
- W1996779897 cites W2013185658 @default.
- W1996779897 cites W2013585426 @default.
- W1996779897 cites W2018272903 @default.
- W1996779897 cites W2020490759 @default.
- W1996779897 cites W2028535639 @default.
- W1996779897 cites W2030502615 @default.
- W1996779897 cites W2034206919 @default.
- W1996779897 cites W2037441307 @default.
- W1996779897 cites W2037472730 @default.
- W1996779897 cites W2037778691 @default.
- W1996779897 cites W2038813826 @default.
- W1996779897 cites W2040630297 @default.
- W1996779897 cites W2042963739 @default.
- W1996779897 cites W2042966900 @default.
- W1996779897 cites W2043685018 @default.
- W1996779897 cites W2046459630 @default.
- W1996779897 cites W2047859447 @default.
- W1996779897 cites W2052700843 @default.
- W1996779897 cites W2053428518 @default.
- W1996779897 cites W2053591294 @default.
- W1996779897 cites W2056496966 @default.
- W1996779897 cites W2058295483 @default.
- W1996779897 cites W2066562615 @default.
- W1996779897 cites W2067080112 @default.
- W1996779897 cites W2068022080 @default.
- W1996779897 cites W2068676111 @default.
- W1996779897 cites W2069186568 @default.
- W1996779897 cites W2069280713 @default.
- W1996779897 cites W2072441360 @default.
- W1996779897 cites W2074909659 @default.
- W1996779897 cites W2080084480 @default.
- W1996779897 cites W2090054406 @default.
- W1996779897 cites W2090381051 @default.
- W1996779897 cites W2090760765 @default.
- W1996779897 cites W2102458112 @default.
- W1996779897 cites W2104600818 @default.
- W1996779897 cites W2112004353 @default.
- W1996779897 cites W2113768395 @default.
- W1996779897 cites W2114452590 @default.
- W1996779897 cites W2114874273 @default.
- W1996779897 cites W2117509905 @default.
- W1996779897 cites W2121198501 @default.
- W1996779897 cites W2123324115 @default.
- W1996779897 cites W2126776792 @default.
- W1996779897 cites W2135086523 @default.
- W1996779897 cites W2135483748 @default.
- W1996779897 cites W2138998026 @default.
- W1996779897 cites W2140937256 @default.
- W1996779897 cites W2142664907 @default.
- W1996779897 cites W2145882488 @default.
- W1996779897 cites W2149591661 @default.
- W1996779897 cites W2165710145 @default.
- W1996779897 cites W2318882207 @default.
- W1996779897 cites W672220 @default.
- W1996779897 doi "https://doi.org/10.1155/2013/514908" @default.
- W1996779897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3625590" @default.
- W1996779897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23606881" @default.
- W1996779897 hasPublicationYear "2013" @default.
- W1996779897 type Work @default.
- W1996779897 sameAs 1996779897 @default.
- W1996779897 citedByCount "11" @default.
- W1996779897 countsByYear W19967798972014 @default.
- W1996779897 countsByYear W19967798972015 @default.
- W1996779897 countsByYear W19967798972016 @default.
- W1996779897 countsByYear W19967798972019 @default.
- W1996779897 countsByYear W19967798972020 @default.
- W1996779897 countsByYear W19967798972021 @default.
- W1996779897 countsByYear W19967798972022 @default.
- W1996779897 crossrefType "journal-article" @default.
- W1996779897 hasAuthorship W1996779897A5001081386 @default.
- W1996779897 hasAuthorship W1996779897A5003646781 @default.
- W1996779897 hasAuthorship W1996779897A5012615787 @default.
- W1996779897 hasAuthorship W1996779897A5013341045 @default.