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- W1996785831 abstract "2013 e83 PP208—Deoxycholic AciD As A MoDifier of the BlooD BrAin BArrier PerMeAtion in rAt M. Lalic-Popovic; S. Golocorbin-Kon; V. Vasovic; B. Milijasevic; and M. Mikov Department of Pharmacy, Faculty of Medicine, Novi Sad, Serbia; Faculty of Pharmacy, University of Montenegro, Podgorica, Montenegro; and Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, Novi Sad, Serbia Introduction: Major problem for diabetic patients represents damage of blood vessels and the oxidative stress of the brain cells due to increased concentration of free radicals and poor nutrition of brain cells. Gliclazide has antioxidative properties and poor blood brain barrier (BBB) penetration. Bile acids are known for their hypoglycemic effect and as prooters of drug penetration across biological membranes. Aim: The aim of this study is to investigate whether the bile acid (deoxycholic acid) can change the permeation of gliclazide, through the blood brain barrier of a rat model type-1 diabetes. Patients (or Materials) and Methods: Twenty-four male Wistar rats were randomly allocated to 4 groups, of which 2 were given alloxan intraperitoneally (100 mg/kg) to induce diabetes. One diabetic group and 1 healthy group were given a bolus gliclazide intra-arterially (20 mg/kg), while the other 2 groups apart from gliclazide got deoxycholic acid (4 mg/kg) subcutaneously. Blood samples were collected 30, 60, 150, and 240 seconds after dose, brain tissues were immediately excised, and blood glucose and gliclazide concentrations were measured. Results: Penetration of gliclazide in groups without deoxycholic acid pretreatment was increased in diabetic animals compared with healthy animals. Also in both, healthy and diabetic animals, deoxycholic acid increased the permeation of gliclazide through that in BBB. Deoxycholic acid pretreatment also changed the pattern of blood glucose level increase after gliclazide application in diabetic as well as in healthy animals. Conclusion: Deoxycholic acid promotes gliclazide penetration across BBB in diabetic and in healthy animals. In addition, deoxycholic acid alters some pharmacokinetic properties of gliclazide in both healthy and diabetic rats. Thus, deoxycholic acid should be more investigated in the treatment of diabetes mellitus and as permeation promoter of lipophilic molecules through BBB as well as other biological membranes. Financial Source: This work has been supported by Ministry of Science and Technology development of Serbia N041012." @default.
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- W1996785831 date "2013-08-01" @default.
- W1996785831 modified "2023-09-22" @default.
- W1996785831 title "PP208—Deoxycholic Acid as a Modifier of the Blood Brain Barrier Permeation in Rat" @default.
- W1996785831 doi "https://doi.org/10.1016/j.clinthera.2013.07.237" @default.
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