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• W1996793931 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Feb 2001AUTOMATED NONINVASIVE MEASUREMENT OF CYCLOPHOSPHAMIDE-INDUCED CHANGES IN MURINE VOIDING FREQUENCY AND VOLUME RONALD WOOD, LOUIS EICHEL, EDWARD M. MESSING, and EDWARD SCHWARZ RONALD WOODRONALD WOOD More articles by this author , LOUIS EICHELLOUIS EICHEL More articles by this author , EDWARD M. MESSINGEDWARD M. MESSING More articles by this author , and EDWARD SCHWARZEDWARD SCHWARZ More articles by this author View All Author Informationhttps://doi.org/10.1097/00005392-200102000-00089AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We developed an automated noninvasive method for studying bladder function in mice. Changes in voided volume and frequency accompanying cyclophosphamide-induced cystitis were measured using computerized digital balances. Materials and Methods: Eight CRL CD-1 mice were given a solution of glucose and saccharin to increase urine output and studied during the dark cycle, when most voiding occurs. Urine fell directly onto electronic balance pans. The time and weight of each void was recorded. Computer programs adjusted for evaporative loss analyzed voiding data within and across sessions. After establishing stable voiding patterns 300 mg./kg. cyclophosphamide were administered intraperitoneally. The Wilcoxon signed rank test was done to compare median voided volumes, frequency and gm. per hour of urine produced before and after cyclophosphamide. Results: We implemented an automated method for voiding studies in mice. After cyclophosphamide administration the number of voids per hour increased and voided volume decreased. Some mice had as much as a 70% decrease in bladder volume and a tripling of urinary frequency. Mice responded by a sustained elevation in frequency and decreased voided volume as early as 24 hours after cyclophosphamide administration or by a pattern of delayed toxicity. Conclusions: This noninvasive technique measures changes in mouse voiding patterns with great sensitivity and minimal effort. The method is applicable to murine models of interstitial cystitis, detrusor instability and other abnormal voiding states. It may be used for evaluating potential therapies for such conditions. References 1 : Interstitial cystitis. In: . Philadelphia: W. B. Saunders1992: 982. chapt. 24. Google Scholar 2 : Bladder damage in mice after combined treatment with cyclophosphamide and X-rays. The influence of timing and sequence. Radiother Oncol1988; 11: 349. Google Scholar 3 : Mechanism of bladder damage and repair after treatment with radiation and cytostatic drugs. Br J Cancer1986; 53: 280. 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Google Scholar Departments of Obstetrics and Gynecology, Urology and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byNegoro H, Kanematsu A, Matsuo M, Okamura H, Tabata Y and Ogawa O (2018) Development of Diurnal Micturition Pattern in Mice After WeaningJournal of Urology, VOL. 189, NO. 2, (740-746), Online publication date: 1-Feb-2013.McCafferty G, Coatney R, Laping N and Thorneloe K (2018) Urodynamic Measurements by Radiotelemetry in Conscious, Freely Moving Beagle DogsJournal of Urology, VOL. 181, NO. 3, (1444-1451), Online publication date: 1-Mar-2009.WESTROPP J and BUFFINGTON C (2018) IN VIVO MODELS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 2 Part 1, (694-702), Online publication date: 1-Feb-2002. Volume 165Issue 2February 2001Page: 653-659 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.KeywordsbladdermicecyclophosphamidecystitisMetricsAuthor Information RONALD WOOD More articles by this author LOUIS EICHEL More articles by this author EDWARD M. MESSING More articles by this author EDWARD SCHWARZ More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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