Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996799211> ?p ?o ?g. }
- W1996799211 endingPage "3262" @default.
- W1996799211 startingPage "3256" @default.
- W1996799211 abstract "Therapeutic doses of zoledronic acid markedly inhibit in vitro proliferation, chemotaxis, and capillarogenesis of bone marrow endothelial cells of patients with multiple myeloma. Zoledronic acid also induces a sizeable reduction of angiogenesis in the in vivo chorioallantoic membrane assay. These effects are partly sustained by gene and protein inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in an autocrine loop. Mevastatin, a specific inhibitor of the mevalonate pathway, reverts the zoledronic acid antiangiogenic effect, indicating that the drug halts this pathway. Our results provide evidence of a direct antiangiogenic activity of zoledronic acid on multiple myeloma patient-derived endothelial cells due to at least four different mechanisms identified either in vitro or in vivo. Tentatively, we suggest that the zoledronic acid antitumoral activity in multiple myeloma is also sustained by antiangiogenesis, which would partly account for its therapeutic efficacy in multiple myeloma." @default.
- W1996799211 created "2016-06-24" @default.
- W1996799211 creator A5012195468 @default.
- W1996799211 creator A5020924212 @default.
- W1996799211 creator A5041415692 @default.
- W1996799211 creator A5054370212 @default.
- W1996799211 creator A5055332109 @default.
- W1996799211 creator A5056803751 @default.
- W1996799211 creator A5061239654 @default.
- W1996799211 creator A5074537397 @default.
- W1996799211 creator A5075051587 @default.
- W1996799211 creator A5078027011 @default.
- W1996799211 creator A5084964560 @default.
- W1996799211 creator A5085962948 @default.
- W1996799211 date "2007-12-01" @default.
- W1996799211 modified "2023-09-23" @default.
- W1996799211 title "Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma" @default.
- W1996799211 cites W1265988497 @default.
- W1996799211 cites W1523196819 @default.
- W1996799211 cites W1896782101 @default.
- W1996799211 cites W1976742426 @default.
- W1996799211 cites W1978228601 @default.
- W1996799211 cites W1981218425 @default.
- W1996799211 cites W1983259674 @default.
- W1996799211 cites W2013187395 @default.
- W1996799211 cites W2031276908 @default.
- W1996799211 cites W2031650256 @default.
- W1996799211 cites W2037548392 @default.
- W1996799211 cites W2076769374 @default.
- W1996799211 cites W2083572243 @default.
- W1996799211 cites W2093164779 @default.
- W1996799211 cites W2101484235 @default.
- W1996799211 cites W2105459402 @default.
- W1996799211 cites W2107277218 @default.
- W1996799211 cites W2132086241 @default.
- W1996799211 cites W2141324982 @default.
- W1996799211 cites W2144860907 @default.
- W1996799211 cites W2164435768 @default.
- W1996799211 cites W2164807675 @default.
- W1996799211 cites W2170411142 @default.
- W1996799211 cites W2415657570 @default.
- W1996799211 cites W4239456483 @default.
- W1996799211 cites W4242024627 @default.
- W1996799211 doi "https://doi.org/10.1158/1535-7163.mct-07-0311" @default.
- W1996799211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18089719" @default.
- W1996799211 hasPublicationYear "2007" @default.
- W1996799211 type Work @default.
- W1996799211 sameAs 1996799211 @default.
- W1996799211 citedByCount "69" @default.
- W1996799211 countsByYear W19967992112012 @default.
- W1996799211 countsByYear W19967992112013 @default.
- W1996799211 countsByYear W19967992112014 @default.
- W1996799211 countsByYear W19967992112015 @default.
- W1996799211 countsByYear W19967992112016 @default.
- W1996799211 countsByYear W19967992112017 @default.
- W1996799211 countsByYear W19967992112018 @default.
- W1996799211 countsByYear W19967992112019 @default.
- W1996799211 countsByYear W19967992112020 @default.
- W1996799211 countsByYear W19967992112022 @default.
- W1996799211 countsByYear W19967992112023 @default.
- W1996799211 crossrefType "journal-article" @default.
- W1996799211 hasAuthorship W1996799211A5012195468 @default.
- W1996799211 hasAuthorship W1996799211A5020924212 @default.
- W1996799211 hasAuthorship W1996799211A5041415692 @default.
- W1996799211 hasAuthorship W1996799211A5054370212 @default.
- W1996799211 hasAuthorship W1996799211A5055332109 @default.
- W1996799211 hasAuthorship W1996799211A5056803751 @default.
- W1996799211 hasAuthorship W1996799211A5061239654 @default.
- W1996799211 hasAuthorship W1996799211A5074537397 @default.
- W1996799211 hasAuthorship W1996799211A5075051587 @default.
- W1996799211 hasAuthorship W1996799211A5078027011 @default.
- W1996799211 hasAuthorship W1996799211A5084964560 @default.
- W1996799211 hasAuthorship W1996799211A5085962948 @default.
- W1996799211 hasBestOaLocation W19967992111 @default.
- W1996799211 hasConcept C126322002 @default.
- W1996799211 hasConcept C128240485 @default.
- W1996799211 hasConcept C134651460 @default.
- W1996799211 hasConcept C150903083 @default.
- W1996799211 hasConcept C170493617 @default.
- W1996799211 hasConcept C181199279 @default.
- W1996799211 hasConcept C203014093 @default.
- W1996799211 hasConcept C207001950 @default.
- W1996799211 hasConcept C2776326535 @default.
- W1996799211 hasConcept C2776364478 @default.
- W1996799211 hasConcept C2779982574 @default.
- W1996799211 hasConcept C2780394083 @default.
- W1996799211 hasConcept C502942594 @default.
- W1996799211 hasConcept C55493867 @default.
- W1996799211 hasConcept C71924100 @default.
- W1996799211 hasConcept C86803240 @default.
- W1996799211 hasConcept C97230052 @default.
- W1996799211 hasConcept C98274493 @default.
- W1996799211 hasConceptScore W1996799211C126322002 @default.
- W1996799211 hasConceptScore W1996799211C128240485 @default.
- W1996799211 hasConceptScore W1996799211C134651460 @default.
- W1996799211 hasConceptScore W1996799211C150903083 @default.
- W1996799211 hasConceptScore W1996799211C170493617 @default.
- W1996799211 hasConceptScore W1996799211C181199279 @default.