FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996802011> ?p ?o ?g. }

• W1996802011 endingPage "e447" @default.
• W1996802011 startingPage "e447" @default.
• W1996802011 abstract "Paracetamol (acetaminophen, APAP) is a universally used analgesic and antipyretic agent. Considered safe at therapeutic doses, overdoses cause acute liver damage characterized by centrilobular hepatic necrosis. One of the major clinical problems of paracetamol-induced liver disease is the development of hemorrhagic alterations. Although hepatocytes represent the main target of the cytotoxic effect of paracetamol overdose, perturbations within the endothelium involving morphological changes of liver sinusoidal endothelial cells (LSECs) have also been described in paracetamol-induced liver disease. Recently, we have shown that paracetamol-induced liver damage is synergistically enhanced by the TRAIL signaling pathway. As LSECs are constantly exposed to activated immune cells expressing death ligands, including TRAIL, we investigated the effect of TRAIL on paracetamol-induced LSEC death. We here demonstrate for the first time that TRAIL strongly enhances paracetamol-mediated LSEC death with typical features of apoptosis. Inhibition of caspases using specific inhibitors resulted in a strong reduction of cell death. TRAIL appears to enhance paracetamol-induced LSEC death via the activation of the pro-apoptotic BH3-only proteins Bid and Bim, which initiate the mitochondrial apoptotic pathway. Taken together this study shows that the liver endothelial layer, mainly LSECs, represent a direct target of the cytotoxic effect of paracetamol and that activation of TRAIL receptor synergistically enhances paracetamol-induced LSEC death via the mitochondrial apoptotic pathway. TRAIL-mediated acceleration of paracetamol-induced cell death may thus contribute to the pathogenesis of paracetamol-induced liver damage." @default.
• W1996802011 created "2016-06-24" @default.
• W1996802011 creator A5010655150 @default.
• W1996802011 creator A5035001405 @default.
• W1996802011 creator A5046291484 @default.
• W1996802011 creator A5068505639 @default.
• W1996802011 creator A5073173188 @default.
• W1996802011 creator A5086583845 @default.
• W1996802011 date "2012-12-20" @default.
• W1996802011 modified "2023-10-08" @default.
• W1996802011 title "TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner" @default.
• W1996802011 cites W1528349069 @default.
• W1996802011 cites W1977402753 @default.
• W1996802011 cites W1981424043 @default.
• W1996802011 cites W1997037955 @default.
• W1996802011 cites W2001786662 @default.
• W1996802011 cites W2004256529 @default.
• W1996802011 cites W2013117655 @default.
• W1996802011 cites W2015479409 @default.
• W1996802011 cites W2036834058 @default.
• W1996802011 cites W2037548392 @default.
• W1996802011 cites W2057368742 @default.
• W1996802011 cites W2060710455 @default.
• W1996802011 cites W2061763404 @default.
• W1996802011 cites W2075101741 @default.
• W1996802011 cites W2076372222 @default.
• W1996802011 cites W2078036072 @default.
• W1996802011 cites W2078422760 @default.
• W1996802011 cites W2080559728 @default.
• W1996802011 cites W2083533385 @default.
• W1996802011 cites W2110572140 @default.
• W1996802011 cites W2111834129 @default.
• W1996802011 cites W2137577984 @default.
• W1996802011 cites W2163882639 @default.
• W1996802011 cites W2219970926 @default.
• W1996802011 cites W4240962591 @default.
• W1996802011 cites W4313347958 @default.
• W1996802011 cites W7512181 @default.
• W1996802011 doi "https://doi.org/10.1038/cddis.2012.185" @default.
• W1996802011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542621" @default.
• W1996802011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23254290" @default.
• W1996802011 hasPublicationYear "2012" @default.
• W1996802011 type Work @default.
• W1996802011 sameAs 1996802011 @default.
• W1996802011 citedByCount "22" @default.
• W1996802011 countsByYear W19968020112014 @default.
• W1996802011 countsByYear W19968020112015 @default.
• W1996802011 countsByYear W19968020112017 @default.
• W1996802011 countsByYear W19968020112018 @default.
• W1996802011 countsByYear W19968020112019 @default.
• W1996802011 countsByYear W19968020112020 @default.
• W1996802011 countsByYear W19968020112021 @default.
• W1996802011 countsByYear W19968020112023 @default.
• W1996802011 crossrefType "journal-article" @default.
• W1996802011 hasAuthorship W1996802011A5010655150 @default.
• W1996802011 hasAuthorship W1996802011A5035001405 @default.
• W1996802011 hasAuthorship W1996802011A5046291484 @default.
• W1996802011 hasAuthorship W1996802011A5068505639 @default.
• W1996802011 hasAuthorship W1996802011A5073173188 @default.
• W1996802011 hasAuthorship W1996802011A5086583845 @default.
• W1996802011 hasBestOaLocation W19968020111 @default.
• W1996802011 hasConcept C109316439 @default.
• W1996802011 hasConcept C126322002 @default.
• W1996802011 hasConcept C142724271 @default.
• W1996802011 hasConcept C154317977 @default.
• W1996802011 hasConcept C185592680 @default.
• W1996802011 hasConcept C190283241 @default.
• W1996802011 hasConcept C202751555 @default.
• W1996802011 hasConcept C2776637226 @default.
• W1996802011 hasConcept C2777075537 @default.
• W1996802011 hasConcept C2778722691 @default.
• W1996802011 hasConcept C31573885 @default.
• W1996802011 hasConcept C502942594 @default.
• W1996802011 hasConcept C503630168 @default.
• W1996802011 hasConcept C55493867 @default.
• W1996802011 hasConcept C71924100 @default.
• W1996802011 hasConcept C86803240 @default.
• W1996802011 hasConcept C98274493 @default.
• W1996802011 hasConcept C98424977 @default.
• W1996802011 hasConceptScore W1996802011C109316439 @default.
• W1996802011 hasConceptScore W1996802011C126322002 @default.
• W1996802011 hasConceptScore W1996802011C142724271 @default.
• W1996802011 hasConceptScore W1996802011C154317977 @default.
• W1996802011 hasConceptScore W1996802011C185592680 @default.
• W1996802011 hasConceptScore W1996802011C190283241 @default.
• W1996802011 hasConceptScore W1996802011C202751555 @default.
• W1996802011 hasConceptScore W1996802011C2776637226 @default.
• W1996802011 hasConceptScore W1996802011C2777075537 @default.
• W1996802011 hasConceptScore W1996802011C2778722691 @default.
• W1996802011 hasConceptScore W1996802011C31573885 @default.
• W1996802011 hasConceptScore W1996802011C502942594 @default.
• W1996802011 hasConceptScore W1996802011C503630168 @default.
• W1996802011 hasConceptScore W1996802011C55493867 @default.
• W1996802011 hasConceptScore W1996802011C71924100 @default.
• W1996802011 hasConceptScore W1996802011C86803240 @default.
• W1996802011 hasConceptScore W1996802011C98274493 @default.
• W1996802011 hasConceptScore W1996802011C98424977 @default.
• W1996802011 hasIssue "12" @default.

• next