Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996804310> ?p ?o ?g. }
- W1996804310 endingPage "S22" @default.
- W1996804310 startingPage "S16" @default.
- W1996804310 abstract "Somatic mutations in certain tyrosine kinases have emerged as central 'drivers' of specific cancers and these mutant proteins are proving to be excellent substrates for targeted therapies. This is the case for mutant EGFR-dependent lung adenocarcinomas, where EGFR mutation testing is already being used to help guide treatment decisions. Here, we provide an overview of the biology of EGFR-targeted therapies and the clinical experience to date, the positive and negative predictors of response, pathologic correlates of EGFR-mutant status, testing methods to establish patient eligibility for these agents, and the basis for primary and secondary resistance." @default.
- W1996804310 created "2016-06-24" @default.
- W1996804310 creator A5046345178 @default.
- W1996804310 creator A5062616992 @default.
- W1996804310 date "2008-04-25" @default.
- W1996804310 modified "2023-10-11" @default.
- W1996804310 title "Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond" @default.
- W1996804310 cites W128476255 @default.
- W1996804310 cites W152953340 @default.
- W1996804310 cites W1969726210 @default.
- W1996804310 cites W1973312323 @default.
- W1996804310 cites W1979332174 @default.
- W1996804310 cites W1980270550 @default.
- W1996804310 cites W1980791428 @default.
- W1996804310 cites W1982397643 @default.
- W1996804310 cites W1988442083 @default.
- W1996804310 cites W1988939419 @default.
- W1996804310 cites W1990774346 @default.
- W1996804310 cites W1992277751 @default.
- W1996804310 cites W1992796124 @default.
- W1996804310 cites W1998971866 @default.
- W1996804310 cites W2002937040 @default.
- W1996804310 cites W2003984225 @default.
- W1996804310 cites W2020166355 @default.
- W1996804310 cites W2025404610 @default.
- W1996804310 cites W2028770753 @default.
- W1996804310 cites W2029155774 @default.
- W1996804310 cites W2030882637 @default.
- W1996804310 cites W2043696829 @default.
- W1996804310 cites W2044186739 @default.
- W1996804310 cites W2055402151 @default.
- W1996804310 cites W2056082272 @default.
- W1996804310 cites W2056625156 @default.
- W1996804310 cites W2068244265 @default.
- W1996804310 cites W2069312070 @default.
- W1996804310 cites W2074937243 @default.
- W1996804310 cites W2079157428 @default.
- W1996804310 cites W2080686146 @default.
- W1996804310 cites W2089545132 @default.
- W1996804310 cites W2093613683 @default.
- W1996804310 cites W2093922887 @default.
- W1996804310 cites W2096436433 @default.
- W1996804310 cites W2096786080 @default.
- W1996804310 cites W2100785570 @default.
- W1996804310 cites W2111599976 @default.
- W1996804310 cites W2111710483 @default.
- W1996804310 cites W2116531093 @default.
- W1996804310 cites W2117036891 @default.
- W1996804310 cites W2117114937 @default.
- W1996804310 cites W2118004874 @default.
- W1996804310 cites W2121389354 @default.
- W1996804310 cites W2124214040 @default.
- W1996804310 cites W2125195105 @default.
- W1996804310 cites W2126004255 @default.
- W1996804310 cites W2127445851 @default.
- W1996804310 cites W2127766722 @default.
- W1996804310 cites W2129736970 @default.
- W1996804310 cites W2133867160 @default.
- W1996804310 cites W2136263263 @default.
- W1996804310 cites W2136390065 @default.
- W1996804310 cites W2138312420 @default.
- W1996804310 cites W2139236349 @default.
- W1996804310 cites W2140775102 @default.
- W1996804310 cites W2141088968 @default.
- W1996804310 cites W2142850084 @default.
- W1996804310 cites W2143171062 @default.
- W1996804310 cites W2143953836 @default.
- W1996804310 cites W2159322582 @default.
- W1996804310 cites W2161821474 @default.
- W1996804310 cites W2166649051 @default.
- W1996804310 cites W2167010023 @default.
- W1996804310 cites W2168554121 @default.
- W1996804310 cites W2168841302 @default.
- W1996804310 cites W3010926306 @default.
- W1996804310 cites W3012214105 @default.
- W1996804310 doi "https://doi.org/10.1038/modpathol.3801018" @default.
- W1996804310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18437168" @default.
- W1996804310 hasPublicationYear "2008" @default.
- W1996804310 type Work @default.
- W1996804310 sameAs 1996804310 @default.
- W1996804310 citedByCount "303" @default.
- W1996804310 countsByYear W19968043102012 @default.
- W1996804310 countsByYear W19968043102013 @default.
- W1996804310 countsByYear W19968043102014 @default.
- W1996804310 countsByYear W19968043102015 @default.
- W1996804310 countsByYear W19968043102016 @default.
- W1996804310 countsByYear W19968043102017 @default.
- W1996804310 countsByYear W19968043102018 @default.
- W1996804310 countsByYear W19968043102019 @default.
- W1996804310 countsByYear W19968043102020 @default.
- W1996804310 countsByYear W19968043102021 @default.
- W1996804310 countsByYear W19968043102022 @default.
- W1996804310 countsByYear W19968043102023 @default.
- W1996804310 crossrefType "journal-article" @default.
- W1996804310 hasAuthorship W1996804310A5046345178 @default.
- W1996804310 hasAuthorship W1996804310A5062616992 @default.
- W1996804310 hasBestOaLocation W19968043101 @default.
- W1996804310 hasConcept C104317684 @default.