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- W1996804582 abstract "MOST of the methods for determining the potency of adrenal cortical extracts are based upon the correction of physiologic changes which occur in the animal organism following adrenalectomy. The observations that adrenalectomized animals exhibit profound changes in electrolyte metabolism and survive only for a short time after operation (Pfiffner, Swingle and Vars 1934), show a markedly impaired muscle efficiency (Ingle 1936) and hepatic glyconeogenesis (Reinecke and Kendall 1942) have been used as the bases for various methods of assay. The sensitivity of adrenalectomized animals to cold environments noted by Elliot (1914), Cannon and Querido (1924) and Wyman and turn Suden (1929) was shown by Hartman, Brownell and Crosby (1931) and by Widstrom (1935) to be decreased by the injection of adrenal cortical extracts. Selye and Schenker (1938) have made use of this phenomenon in the development of an assay method for the detection of minute quantities of adrenal cortical activity." @default.
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- W1996804582 date "1943-11-01" @default.
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- W1996804582 title "ASSAY OF ADRENAL CORTICAL EXTRACTS IN ADRENALECTOMIZED RATS EXPOSED TO COLD1" @default.
- W1996804582 doi "https://doi.org/10.1210/endo-33-5-276" @default.
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