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• W1996806962 abstract "Metastasis is a key aspect of tumor malignancy, and several malignant tumors show expression of various mature N-type glycans. In particular, β1-6 branching N-acetylglucosamine (GlcNAc) is abundantly expressed as a part of high-mannose glycans in various highly metastatic cancers. Phaseolus vulgaris agglutinin-L4 isolectin (L4-PHA), which adheres to β1-6 GlcNAc specifically, has been used for in situ cancer diagnosis. Bionanocapsules (BNCs), hollow particles with a diameter of approximately 80 nm and composed of hepatitis B surface antigen (HBsAg) and a lipid bilayer, have been developed as human liver-specific nanocapsules for in vivo drug delivery system. In this study, we have generated L4-PHA-displaying BNCs (PHA–BNCs) and examined whether L4-PHA could retarget the BNCs to malignant tumors as a “biosensor” distinguishing tumor metastaticity. Fluorescence-labeled PHA–BNCs injected systemically into a mouse xenograft model were found to accumulate in β1-6 GlcNAc-expressing malignant tumors. The PHA–BNCs were able to deliver DNA to the malignant cancer cells. These results open up the possibility of using L4-PHA lectin as a targeting molecule in a drug delivery system, and of using PHA–BNCs as a novel nanodevice for malignant tumor-specific bioimaging and drug delivery." @default.
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• W1996806962 date "2008-09-01" @default.
• W1996806962 modified "2023-09-26" @default.
• W1996806962 title "<i>In Vivo</i>Delivery of Bionanocapsules Displaying<i>Phaseolus vulgaris</i>Agglutinin-L₄Isolectin to Malignant Tumors Overexpressing<i>N</i>-Acetylglucosaminyltransferase V" @default.
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• W1996806962 doi "https://doi.org/10.1089/hum.2008.037" @default.
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