FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996807918> ?p ?o ?g. }

• W1996807918 endingPage "241" @default.
• W1996807918 startingPage "231" @default.
• W1996807918 abstract "Objective The underlying effect of serotonergic neurotransmission has been implicated in several psychiatric disorders. The inability to routinely and non-invasively determine the integrity of the serotonergic system in vivo has limited our understanding of disorders with a putative serotonergic abnormality. The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a reliable measure of central serotonin function in humans. While animal studies suggest that the LDAEP is sensitive to changes in central serotonin neurotransmission, evidence in humans has been indirect and inconsistent. The aim of this study was to assess the sensitivity of the LDAEP to acute augmentation in central serotonergic neurotransmission in humans. Methods The study used a double-blind, placebo-controlled cross-over design, in which healthy subjects were tested under four acute treatment conditions, with pharmacologically equivalent single doses of placebo, escitalopram (10 mg), citalopram (20 mg) and sertraline (50 mg) to examine the direct effect of acute enhancement of synaptic serotonin on the LDAEP. Furthermore, the outcome of the serotonergic modulatory effects on the LDAEP was also examined using two methods (dipole source analysis (DSA) vs. scalp analysis). Results Escitalopram, citalopram and sertraline had no effects on the LDAEP and were independent of the analysis method used. Conclusion These findings question the sensitivity of the LDAEP to acute changes in serotonin neurotransmission and its validity as a reliable measure of central serotonin function in humans. Copyright © 2008 John Wiley & Sons, Ltd." @default.
• W1996807918 created "2016-06-24" @default.
• W1996807918 creator A5008050057 @default.
• W1996807918 creator A5016467973 @default.
• W1996807918 creator A5018958936 @default.
• W1996807918 creator A5020209022 @default.
• W1996807918 creator A5027917089 @default.
• W1996807918 creator A5052990226 @default.
• W1996807918 date "2008-01-01" @default.
• W1996807918 modified "2023-10-08" @default.
• W1996807918 title "An examination of acute changes in serotonergic neurotransmission using the loudness dependence measure of auditory cortex evoked activity: effects of citalopram, escitalopram and sertraline" @default.
• W1996807918 cites W1964678898 @default.
• W1996807918 cites W1970404912 @default.
• W1996807918 cites W1971385161 @default.
• W1996807918 cites W1971723831 @default.
• W1996807918 cites W1981011630 @default.
• W1996807918 cites W1981415377 @default.
• W1996807918 cites W1983058174 @default.
• W1996807918 cites W1990493255 @default.
• W1996807918 cites W1992180002 @default.
• W1996807918 cites W1997437851 @default.
• W1996807918 cites W2001012944 @default.
• W1996807918 cites W2015599047 @default.
• W1996807918 cites W2019611550 @default.
• W1996807918 cites W2021703263 @default.
• W1996807918 cites W2022497945 @default.
• W1996807918 cites W2028129568 @default.
• W1996807918 cites W2028194357 @default.
• W1996807918 cites W2032398284 @default.
• W1996807918 cites W2032465820 @default.
• W1996807918 cites W2038890438 @default.
• W1996807918 cites W2042959928 @default.
• W1996807918 cites W2044359142 @default.
• W1996807918 cites W2045811631 @default.
• W1996807918 cites W2046481066 @default.
• W1996807918 cites W2048283236 @default.
• W1996807918 cites W2049692833 @default.
• W1996807918 cites W2051068515 @default.
• W1996807918 cites W2052106863 @default.
• W1996807918 cites W2055098509 @default.
• W1996807918 cites W2066840817 @default.
• W1996807918 cites W2069881284 @default.
• W1996807918 cites W2076639163 @default.
• W1996807918 cites W2082363592 @default.
• W1996807918 cites W2083864893 @default.
• W1996807918 cites W2084333656 @default.
• W1996807918 cites W2085502898 @default.
• W1996807918 cites W2091457274 @default.
• W1996807918 cites W2091587926 @default.
• W1996807918 cites W2094965887 @default.
• W1996807918 cites W2096266931 @default.
• W1996807918 cites W2108989220 @default.
• W1996807918 cites W2111736228 @default.
• W1996807918 cites W2112235175 @default.
• W1996807918 cites W2121809100 @default.
• W1996807918 cites W2123649031 @default.
• W1996807918 cites W2139026473 @default.
• W1996807918 cites W2143591430 @default.
• W1996807918 cites W2145806711 @default.
• W1996807918 cites W2153148032 @default.
• W1996807918 cites W2155043582 @default.
• W1996807918 cites W2214292935 @default.
• W1996807918 cites W2226359885 @default.
• W1996807918 cites W2546813442 @default.
• W1996807918 doi "https://doi.org/10.1002/hup.922" @default.
• W1996807918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18196604" @default.
• W1996807918 hasPublicationYear "2008" @default.
• W1996807918 type Work @default.
• W1996807918 sameAs 1996807918 @default.
• W1996807918 citedByCount "32" @default.
• W1996807918 countsByYear W19968079182012 @default.
• W1996807918 countsByYear W19968079182013 @default.
• W1996807918 countsByYear W19968079182014 @default.
• W1996807918 countsByYear W19968079182015 @default.
• W1996807918 countsByYear W19968079182018 @default.
• W1996807918 countsByYear W19968079182020 @default.
• W1996807918 countsByYear W19968079182022 @default.
• W1996807918 countsByYear W19968079182023 @default.
• W1996807918 crossrefType "journal-article" @default.
• W1996807918 hasAuthorship W1996807918A5008050057 @default.
• W1996807918 hasAuthorship W1996807918A5016467973 @default.
• W1996807918 hasAuthorship W1996807918A5018958936 @default.
• W1996807918 hasAuthorship W1996807918A5020209022 @default.
• W1996807918 hasAuthorship W1996807918A5027917089 @default.
• W1996807918 hasAuthorship W1996807918A5052990226 @default.
• W1996807918 hasConcept C126322002 @default.
• W1996807918 hasConcept C15744967 @default.
• W1996807918 hasConcept C169760540 @default.
• W1996807918 hasConcept C170493617 @default.
• W1996807918 hasConcept C200170125 @default.
• W1996807918 hasConcept C2775864247 @default.
• W1996807918 hasConcept C2777490545 @default.
• W1996807918 hasConcept C2777669559 @default.
• W1996807918 hasConcept C2779177272 @default.
• W1996807918 hasConcept C2779583969 @default.
• W1996807918 hasConcept C2781161787 @default.
• W1996807918 hasConcept C31487548 @default.
• W1996807918 hasConcept C37000724 @default.

• next