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• W1996813025 abstract "F4+ enterotoxigenic Escherichia coli (ETEC) infections are an important cause of postweaning diarrhoea in piglets and an oral immunization of piglets with purified F4 fimbriae protects them from a subsequent F4+ ETEC infection. However, oral immunization of suckling piglets is hampered due to the immature status of their immune system. Targeting of antigens to Fcγ receptors (FcγR) on human and murine dendritic cells (DC) has been shown to enhance DC maturation and both humoral and cellular immune responses. To investigate the effect of F4 fimbriae incorporated in immune complexes (F4-IC) on porcine DC, we used porcine monocytic-derived DC (MoDC) as a model system. The results in this study demonstrate that FcγRI, II and III mRNA is expressed by porcine MoDC. Furthermore, we show that FcγRII and III are expressed on the cell surface and that F4-IC are internalized by MoDC via FcγR. This FcγR ligation induced a significantly enhanced expression of Major Histocompatibility complex (MHCII) class II and the costimulatory molecules CD80/86 and CD40 by MoDC compared with immature MoDC. Furthermore, the phagocytic capacity of F4-IC stimulated MoDC was reduced as evidenced by a reduced uptake of DQ-ovalbumin and FITC-dextran. In an allogenic and autologous mixed lymphocyte reaction, these F4-IC-activated MoDC showed an improved T cell stimulatory capacity in comparison with immature MoDC. The F4-IC induced DC maturation correlated with significant higher expression levels of several pro-inflammatory cytokines such as interleukine (IL) 1β, IL-6 and Tumor necrosis factor α, the chemokine IL-8 and IL-12p40 in comparison with immature MoDC. Altogether, these results clearly demonstrate that FcγR engagement enhances the maturation of porcine MoDC, which may suggest that antigen targeting to FcγR on DC could improve vaccine design against infections." @default.
• W1996813025 created "2016-06-24" @default.
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• W1996813025 date "2010-06-01" @default.
• W1996813025 modified "2023-09-25" @default.
• W1996813025 title "Targeting of Escherichia coli F4 fimbriae to Fcγ receptors enhances the maturation of porcine dendritic cells" @default.
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• W1996813025 doi "https://doi.org/10.1016/j.vetimm.2009.11.013" @default.
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