Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996828131> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1996828131 endingPage "829" @default.
- W1996828131 startingPage "821" @default.
- W1996828131 abstract "N-Butyldeoxynojirimycin (NB-DNJ) inhibits the ceramide glucosyltransferase which catalyses the first step in glycosphingolipid (GSL) biosynthesis. It has the potential to be used for the treatment of the GSL lysosomal storage diseases and is currently in clinical trials for the treatment of type 1 Gaucher's disease. However, NB-DNJ is also a potent inhibitor of other enzymes, including alpha-glucosidase I and II, which could potentially cause side effects in patients receiving life-long therapy. Wetherefore evaluated a potentially more selective GSL biosynthesis inhibitor, N-butyldeoxygalactonojirimycin (NB-DGJ), in vitro and in vivo. The distribution and degree of GSL depletion in the liver of mice treated with NB-DGJ or NB-DNJ were equivalent. Mice treated with NB-DGJ had normal body weights and lymphoid organ sizes, whereas NB-DNJ-treated mice showed weight loss and partial lymphoid organ shrinkage. NB-DNJ inhibited glycogen catabolism in the liver, whereas NB-DGJ did not. NB-DNJ was also a potent inhibitor of sucrase and maltase in vitro but not of lactase, while NB-DGJ inhibited lactase but not sucrase or maltase. NB-DGJ is therefore more selective than NB-DNJ, and deserves to be evaluated for human therapy." @default.
- W1996828131 created "2016-06-24" @default.
- W1996828131 creator A5062018516 @default.
- W1996828131 creator A5076658123 @default.
- W1996828131 creator A5078895245 @default.
- W1996828131 creator A5086827706 @default.
- W1996828131 date "2000-04-01" @default.
- W1996828131 modified "2023-09-26" @default.
- W1996828131 title "N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo" @default.
- W1996828131 cites W1485152739 @default.
- W1996828131 cites W1595759126 @default.
- W1996828131 cites W1625674217 @default.
- W1996828131 cites W1966498983 @default.
- W1996828131 cites W1988193452 @default.
- W1996828131 cites W1994487284 @default.
- W1996828131 cites W2003532963 @default.
- W1996828131 cites W2011007517 @default.
- W1996828131 cites W2032826794 @default.
- W1996828131 cites W2040046670 @default.
- W1996828131 cites W2064430381 @default.
- W1996828131 cites W2076780197 @default.
- W1996828131 cites W2078379563 @default.
- W1996828131 cites W2093006217 @default.
- W1996828131 cites W2102462689 @default.
- W1996828131 cites W2105603882 @default.
- W1996828131 cites W2144456776 @default.
- W1996828131 cites W2329919173 @default.
- W1996828131 cites W2417855143 @default.
- W1996828131 cites W4247717176 @default.
- W1996828131 cites W2017411361 @default.
- W1996828131 cites W2115864709 @default.
- W1996828131 doi "https://doi.org/10.1016/s0006-2952(99)00384-6" @default.
- W1996828131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10718340" @default.
- W1996828131 hasPublicationYear "2000" @default.
- W1996828131 type Work @default.
- W1996828131 sameAs 1996828131 @default.
- W1996828131 citedByCount "128" @default.
- W1996828131 countsByYear W19968281312012 @default.
- W1996828131 countsByYear W19968281312013 @default.
- W1996828131 countsByYear W19968281312014 @default.
- W1996828131 countsByYear W19968281312015 @default.
- W1996828131 countsByYear W19968281312016 @default.
- W1996828131 countsByYear W19968281312017 @default.
- W1996828131 countsByYear W19968281312018 @default.
- W1996828131 countsByYear W19968281312019 @default.
- W1996828131 countsByYear W19968281312021 @default.
- W1996828131 countsByYear W19968281312022 @default.
- W1996828131 countsByYear W19968281312023 @default.
- W1996828131 crossrefType "journal-article" @default.
- W1996828131 hasAuthorship W1996828131A5062018516 @default.
- W1996828131 hasAuthorship W1996828131A5076658123 @default.
- W1996828131 hasAuthorship W1996828131A5078895245 @default.
- W1996828131 hasAuthorship W1996828131A5086827706 @default.
- W1996828131 hasConcept C150903083 @default.
- W1996828131 hasConcept C181199279 @default.
- W1996828131 hasConcept C185592680 @default.
- W1996828131 hasConcept C202751555 @default.
- W1996828131 hasConcept C207001950 @default.
- W1996828131 hasConcept C2776039999 @default.
- W1996828131 hasConcept C2776931407 @default.
- W1996828131 hasConcept C2778649499 @default.
- W1996828131 hasConcept C55493867 @default.
- W1996828131 hasConcept C86803240 @default.
- W1996828131 hasConcept C98274493 @default.
- W1996828131 hasConceptScore W1996828131C150903083 @default.
- W1996828131 hasConceptScore W1996828131C181199279 @default.
- W1996828131 hasConceptScore W1996828131C185592680 @default.
- W1996828131 hasConceptScore W1996828131C202751555 @default.
- W1996828131 hasConceptScore W1996828131C207001950 @default.
- W1996828131 hasConceptScore W1996828131C2776039999 @default.
- W1996828131 hasConceptScore W1996828131C2776931407 @default.
- W1996828131 hasConceptScore W1996828131C2778649499 @default.
- W1996828131 hasConceptScore W1996828131C55493867 @default.
- W1996828131 hasConceptScore W1996828131C86803240 @default.
- W1996828131 hasConceptScore W1996828131C98274493 @default.
- W1996828131 hasIssue "7" @default.
- W1996828131 hasLocation W19968281311 @default.
- W1996828131 hasLocation W19968281312 @default.
- W1996828131 hasOpenAccess W1996828131 @default.
- W1996828131 hasPrimaryLocation W19968281311 @default.
- W1996828131 hasRelatedWork W130010948 @default.
- W1996828131 hasRelatedWork W1572012021 @default.
- W1996828131 hasRelatedWork W1983855168 @default.
- W1996828131 hasRelatedWork W2032431389 @default.
- W1996828131 hasRelatedWork W2374599087 @default.
- W1996828131 hasRelatedWork W2401495086 @default.
- W1996828131 hasRelatedWork W2414663335 @default.
- W1996828131 hasRelatedWork W2433311123 @default.
- W1996828131 hasRelatedWork W2804375661 @default.
- W1996828131 hasRelatedWork W2953758866 @default.
- W1996828131 hasVolume "59" @default.
- W1996828131 isParatext "false" @default.
- W1996828131 isRetracted "false" @default.
- W1996828131 magId "1996828131" @default.
- W1996828131 workType "article" @default.