FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996833501> ?p ?o ?g. }

• W1996833501 endingPage "445" @default.
• W1996833501 startingPage "435" @default.
• W1996833501 abstract "This tail-flick withdrawal reflex commonly is used to study spinal nociceptive mechanisms; noradrenergic agonists administered intrathecally inhibit the tail-flick- reflex in a dose-dependent manner. The objectives of the present study, were: (1) to use fos-like immunoreactivity as a marker for neuronal activity to examine the population of neurons in the spinal cord dorsal horn that are engaged by activation of nociceptive tail afferents, and (2) to determine whether fos-like immunoreactivity can be modulated by intrathecally administered alpha adrenoceptor agonists. Neurons demonstrating heat-evoked fos-like immunoreactivity were identified bilaterally in the sacral spinal cord in superficial and deep dorsal horn laminae. Heat-evoked fos-like immunoreactivity was inhibited dose-dependently by intrathecal norepinephrine (NE). The inhibition was attenuated significantly by: (1) phentolamine (PHEN), a nonselective alpha adrenoceptor antagonist; (2) yohimbine (YOH), an alpha-2 adrenoceptor antagonist; and (3) prazosin (PRAZ), an alpha-1 adrenoceptor antagonist. Thus, both spinal alpha-1 and alpha-2 adrenoceptors mediate the inhibition of heat-evoked fos-like immunoreactivity produced by intrathecal NE. ST-91, an alpha-2 adrenoceptor agonist, also inhibited significantly the expression of fos-like immunoreactivity; the inhibition was antagonized by YOH. In the absence of noxious heat, intrathecal NE dose-dependently evoked the expression of fos-like immunoreactivity in the superficial dorsal horn, which was antagonized by PHEN and PRAZ, but not by YOH, suggesting that the effect is mediated by spinal alpha-1 adrenoceptors. © 1992 Wiley-Liss, Inc." @default.
• W1996833501 created "2016-06-24" @default.
• W1996833501 creator A5053149676 @default.
• W1996833501 date "1992-11-15" @default.
• W1996833501 modified "2023-10-16" @default.
• W1996833501 title "Noradrenergic modulation of noxious heat-evoked fos-like immunoreactivity in the dorsal horn of the rat sacral spinal cord" @default.
• W1996833501 cites W1026468762 @default.
• W1996833501 cites W1512093443 @default.
• W1996833501 cites W1537638589 @default.
• W1996833501 cites W1573112817 @default.
• W1996833501 cites W1895247602 @default.
• W1996833501 cites W1964941501 @default.
• W1996833501 cites W1970474009 @default.
• W1996833501 cites W1972211185 @default.
• W1996833501 cites W1980809566 @default.
• W1996833501 cites W1982324672 @default.
• W1996833501 cites W1984929776 @default.
• W1996833501 cites W1989138468 @default.
• W1996833501 cites W1991819390 @default.
• W1996833501 cites W1996283992 @default.
• W1996833501 cites W1997114005 @default.
• W1996833501 cites W1998514242 @default.
• W1996833501 cites W2001026574 @default.
• W1996833501 cites W2003102216 @default.
• W1996833501 cites W2008897859 @default.
• W1996833501 cites W2019446637 @default.
• W1996833501 cites W2029806277 @default.
• W1996833501 cites W2040725197 @default.
• W1996833501 cites W2050194934 @default.
• W1996833501 cites W2053047652 @default.
• W1996833501 cites W2054249090 @default.
• W1996833501 cites W2057870229 @default.
• W1996833501 cites W2059433193 @default.
• W1996833501 cites W2067175674 @default.
• W1996833501 cites W2075105186 @default.
• W1996833501 cites W2077133145 @default.
• W1996833501 cites W2091705771 @default.
• W1996833501 cites W2094325656 @default.
• W1996833501 cites W2126764967 @default.
• W1996833501 cites W2129530315 @default.
• W1996833501 cites W2167541848 @default.
• W1996833501 cites W2398218032 @default.
• W1996833501 cites W2466119156 @default.
• W1996833501 cites W4300850161 @default.
• W1996833501 cites W47944928 @default.
• W1996833501 doi "https://doi.org/10.1002/cne.903250309" @default.
• W1996833501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1360018" @default.
• W1996833501 hasPublicationYear "1992" @default.
• W1996833501 type Work @default.
• W1996833501 sameAs 1996833501 @default.
• W1996833501 citedByCount "37" @default.
• W1996833501 countsByYear W19968335012012 @default.
• W1996833501 countsByYear W19968335012014 @default.
• W1996833501 countsByYear W19968335012015 @default.
• W1996833501 countsByYear W19968335012022 @default.
• W1996833501 crossrefType "journal-article" @default.
• W1996833501 hasAuthorship W1996833501A5053149676 @default.
• W1996833501 hasConcept C104211972 @default.
• W1996833501 hasConcept C126322002 @default.
• W1996833501 hasConcept C134018914 @default.
• W1996833501 hasConcept C15490471 @default.
• W1996833501 hasConcept C169760540 @default.
• W1996833501 hasConcept C170493617 @default.
• W1996833501 hasConcept C185592680 @default.
• W1996833501 hasConcept C2776885963 @default.
• W1996833501 hasConcept C2777676773 @default.
• W1996833501 hasConcept C2778514916 @default.
• W1996833501 hasConcept C2778938600 @default.
• W1996833501 hasConcept C2780253649 @default.
• W1996833501 hasConcept C2780648677 @default.
• W1996833501 hasConcept C2780775167 @default.
• W1996833501 hasConcept C2908647359 @default.
• W1996833501 hasConcept C513476851 @default.
• W1996833501 hasConcept C71924100 @default.
• W1996833501 hasConcept C86803240 @default.
• W1996833501 hasConcept C99454951 @default.
• W1996833501 hasConceptScore W1996833501C104211972 @default.
• W1996833501 hasConceptScore W1996833501C126322002 @default.
• W1996833501 hasConceptScore W1996833501C134018914 @default.
• W1996833501 hasConceptScore W1996833501C15490471 @default.
• W1996833501 hasConceptScore W1996833501C169760540 @default.
• W1996833501 hasConceptScore W1996833501C170493617 @default.
• W1996833501 hasConceptScore W1996833501C185592680 @default.
• W1996833501 hasConceptScore W1996833501C2776885963 @default.
• W1996833501 hasConceptScore W1996833501C2777676773 @default.
• W1996833501 hasConceptScore W1996833501C2778514916 @default.
• W1996833501 hasConceptScore W1996833501C2778938600 @default.
• W1996833501 hasConceptScore W1996833501C2780253649 @default.
• W1996833501 hasConceptScore W1996833501C2780648677 @default.
• W1996833501 hasConceptScore W1996833501C2780775167 @default.
• W1996833501 hasConceptScore W1996833501C2908647359 @default.
• W1996833501 hasConceptScore W1996833501C513476851 @default.
• W1996833501 hasConceptScore W1996833501C71924100 @default.
• W1996833501 hasConceptScore W1996833501C86803240 @default.
• W1996833501 hasConceptScore W1996833501C99454951 @default.
• W1996833501 hasIssue "3" @default.
• W1996833501 hasLocation W19968335011 @default.
• W1996833501 hasLocation W19968335012 @default.

• next