Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996834128> ?p ?o ?g. }
- W1996834128 endingPage "292" @default.
- W1996834128 startingPage "280" @default.
- W1996834128 abstract "Murine leukemia virus (MuLV) genome encodes a protease (Y. Yoshinaka, I. Katoh, T. D. Copeland, and S. Oroszlan [dy1985), Proc Nail. Acad. Sci. USA 82,1618–1622), which has been shown to cause maturation, specified as morphological conversion from “immature” to “mature” form of virus cores. To examine whether “immature” particles have infectivity or not, we constructed mutant DNAs with deletions in the protease region. The NIH/3T3 cells transfected with mutant DNAs produced “immature” particles, having immature morphology and containing Pr659gag, a polyprotein precursor of core proteins. The specific infectivity of the extracellularly released and purified particles was shown to be greatly reduced based on reverse transcriptase activity and protein content as compared with the “mature” particles obtained from wild-type DNA-transfected cells. The mutant genomes encoded functionally normal surface glycoprotein, gp70. These results strongly suggest that maturation of MuLV from “immature” to “mature” form of virus particles is indispensable to virus infectivity. The importance of processing of gag and pol, as well as transmembrane protein precursors by the viral protease is discussed." @default.
- W1996834128 created "2016-06-24" @default.
- W1996834128 creator A5008512853 @default.
- W1996834128 creator A5013416863 @default.
- W1996834128 creator A5027147186 @default.
- W1996834128 creator A5037739256 @default.
- W1996834128 creator A5058213173 @default.
- W1996834128 creator A5081214199 @default.
- W1996834128 date "1985-09-01" @default.
- W1996834128 modified "2023-10-11" @default.
- W1996834128 title "Murine leukemia virus maturation: Protease region required for conversion from “immature” to “Mature” core form and for virus infectivity" @default.
- W1996834128 cites W147221144 @default.
- W1996834128 cites W1544126343 @default.
- W1996834128 cites W1570782185 @default.
- W1996834128 cites W1578780209 @default.
- W1996834128 cites W1597803784 @default.
- W1996834128 cites W1601598421 @default.
- W1996834128 cites W1724265809 @default.
- W1996834128 cites W1917673728 @default.
- W1996834128 cites W1928593456 @default.
- W1996834128 cites W1965372133 @default.
- W1996834128 cites W1970081885 @default.
- W1996834128 cites W1997110527 @default.
- W1996834128 cites W2005958149 @default.
- W1996834128 cites W2009414148 @default.
- W1996834128 cites W2010500891 @default.
- W1996834128 cites W2017241147 @default.
- W1996834128 cites W2030673136 @default.
- W1996834128 cites W2033808264 @default.
- W1996834128 cites W2035299947 @default.
- W1996834128 cites W2041162527 @default.
- W1996834128 cites W2056405362 @default.
- W1996834128 cites W2068066098 @default.
- W1996834128 cites W2068193406 @default.
- W1996834128 cites W2069416922 @default.
- W1996834128 cites W2078486513 @default.
- W1996834128 cites W2094657382 @default.
- W1996834128 cites W2098832937 @default.
- W1996834128 cites W2100837269 @default.
- W1996834128 doi "https://doi.org/10.1016/0042-6822(85)90161-8" @default.
- W1996834128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2411050" @default.
- W1996834128 hasPublicationYear "1985" @default.
- W1996834128 type Work @default.
- W1996834128 sameAs 1996834128 @default.
- W1996834128 citedByCount "226" @default.
- W1996834128 countsByYear W19968341282012 @default.
- W1996834128 countsByYear W19968341282013 @default.
- W1996834128 countsByYear W19968341282014 @default.
- W1996834128 countsByYear W19968341282015 @default.
- W1996834128 countsByYear W19968341282016 @default.
- W1996834128 countsByYear W19968341282018 @default.
- W1996834128 countsByYear W19968341282021 @default.
- W1996834128 countsByYear W19968341282023 @default.
- W1996834128 crossrefType "journal-article" @default.
- W1996834128 hasAuthorship W1996834128A5008512853 @default.
- W1996834128 hasAuthorship W1996834128A5013416863 @default.
- W1996834128 hasAuthorship W1996834128A5027147186 @default.
- W1996834128 hasAuthorship W1996834128A5037739256 @default.
- W1996834128 hasAuthorship W1996834128A5058213173 @default.
- W1996834128 hasAuthorship W1996834128A5081214199 @default.
- W1996834128 hasConcept C104317684 @default.
- W1996834128 hasConcept C106358424 @default.
- W1996834128 hasConcept C108625454 @default.
- W1996834128 hasConcept C143065580 @default.
- W1996834128 hasConcept C153911025 @default.
- W1996834128 hasConcept C159047783 @default.
- W1996834128 hasConcept C181199279 @default.
- W1996834128 hasConcept C2522874641 @default.
- W1996834128 hasConcept C2776714187 @default.
- W1996834128 hasConcept C2778431562 @default.
- W1996834128 hasConcept C2778645089 @default.
- W1996834128 hasConcept C2779562191 @default.
- W1996834128 hasConcept C54009773 @default.
- W1996834128 hasConcept C54355233 @default.
- W1996834128 hasConcept C55493867 @default.
- W1996834128 hasConcept C81885089 @default.
- W1996834128 hasConcept C86803240 @default.
- W1996834128 hasConceptScore W1996834128C104317684 @default.
- W1996834128 hasConceptScore W1996834128C106358424 @default.
- W1996834128 hasConceptScore W1996834128C108625454 @default.
- W1996834128 hasConceptScore W1996834128C143065580 @default.
- W1996834128 hasConceptScore W1996834128C153911025 @default.
- W1996834128 hasConceptScore W1996834128C159047783 @default.
- W1996834128 hasConceptScore W1996834128C181199279 @default.
- W1996834128 hasConceptScore W1996834128C2522874641 @default.
- W1996834128 hasConceptScore W1996834128C2776714187 @default.
- W1996834128 hasConceptScore W1996834128C2778431562 @default.
- W1996834128 hasConceptScore W1996834128C2778645089 @default.
- W1996834128 hasConceptScore W1996834128C2779562191 @default.
- W1996834128 hasConceptScore W1996834128C54009773 @default.
- W1996834128 hasConceptScore W1996834128C54355233 @default.
- W1996834128 hasConceptScore W1996834128C55493867 @default.
- W1996834128 hasConceptScore W1996834128C81885089 @default.
- W1996834128 hasConceptScore W1996834128C86803240 @default.
- W1996834128 hasIssue "2" @default.
- W1996834128 hasLocation W19968341281 @default.
- W1996834128 hasLocation W19968341282 @default.
- W1996834128 hasOpenAccess W1996834128 @default.