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• W1996854476 abstract "The Saccharomyces cerevisiae (Sc) PTS1 import receptor Pex5p is modified by ubiquitin, both in an Ubc4p-dependent and a Pex4p (Ubc10p)-dependent manner. Both of these modifications require the RING domain-containing protein Pex10p in vivo, but the actual role this protein plays in the ubiquitination of Pex5p has so far, remained enigmatic. Here, we report that the RING domain of Pex10p exhibits E3 ligase activity in vitro, in combination with the human E2 enzyme UbcH5a, a homologue of ScUbc4p, but not when ScPex4p was used as an E2 enzyme in the reaction. We have further characterised Pex10p’s E3 ligase activity using mutants designed to disturb this activity and show that Pex10p acts as the E3 ligase for Ubc4p-dependent ubiquitination of Pex5p but not Pex4p-dependent ubiquitination in vivo. These data imply that the two distinct Pex5p modifications require different E3 ligases, as well as different E2 enzymes." @default.
• W1996854476 created "2016-06-24" @default.
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• W1996854476 date "2008-10-01" @default.
• W1996854476 modified "2023-10-07" @default.
• W1996854476 title "Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p" @default.
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• W1996854476 doi "https://doi.org/10.1016/j.bbrc.2008.07.054" @default.
• W1996854476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18644345" @default.
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