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- W1996854593 abstract "Since 1972, significant mesangial IgA deposition was detected in 19 patients (16 male, 3 female), undergoing renal biopsy for recurrent gross hematuria (n=15) or asymptomatic urinary abnormalities (n=4). The mean age of diagnosis was 13.5 yrs (range8-18 yrs). Significant proteinuria (> 4mg/M2/hr was detected in 11 patients (x=24.3mg/M2/hr); 8 of these 11 patients had at least one episode of gross hematuria. Glomerular filtration rate (GFR) was normal at the time of diagnosis in all patients. Three patients had reversible reduction in GFR of 20-64% during episodes of gross hematuria. No patients had experienced hypertension. Histopathology varied from completely normal (n=3) to focal and segmental proliferative glomerulonephritis. Capsular adhesions of sclerosed segments were seen in 6 patients and organizing crescents in 2 patients. Six patients had global sclerosis- Immunofluorescence studies revealed C3 in 15 patients, IgG in 8 pts., and IgM in 5 pts. Follow-up in 11 pts. (x=3 yrs), has shown persistence of the clinical pattern, urinary abnormalities and maintenance of GFR Therefore, IgA nephropathy appears to have a more benign histopathology in children and adolescents." @default.
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- W1996854593 date "1981-04-01" @default.
- W1996854593 modified "2023-10-18" @default.
- W1996854593 title "1552 CLINICAL AND HISTOLOGICAL SPECTRUM OF IgA NEPHROPATHY IN CHILDREN AND ADOLESCENTS" @default.
- W1996854593 doi "https://doi.org/10.1203/00006450-198104001-01569" @default.
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