FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996861982> ?p ?o ?g. }

• W1996861982 endingPage "302" @default.
• W1996861982 startingPage "297" @default.
• W1996861982 abstract "OBJECTIVE: Our prime objective was to study the production of big endothelin-1 (Big ET-1) and its conversion to ET-1 in the lungs of newborn rabbits exposed to meconium. Our second objective was to study the effect of captopril on endothelin expression. DESIGN: Prospective, comparative study. SETTING: Research laboratory of the Michael Reese Hospital and the University of Illinois, Chicago. SUBJECTS: Two-wk-old rabbit pups. INTERVENTIONS: Rabbit pups were instilled with meconium or saline into the lungs. Another group, pretreated with captopril, was also instilled with either meconium or saline. MEASUREMENTS AND MAIN RESULTS: After meconium or saline instillation, lung lavage was performed. Big ET-1 and ET-1 were measured in lung lavage fluid by using a commercially available enzyme-linked immunosorbent assay kits in all groups. Also, lungs were studied by histochemistry analysis for a morphologic evaluation of meconium-induced damage. In the lavage fluid of saline-instilled pups, ET-1 remained low and no increase in Big ET-1 levels was observed. In meconium-instilled animals, bioactive ET-1 levels were significantly higher, with a peak at 8 hrs after instillation. The conversion ratio of Big ET-1 to ET-1 in the meconium group increased from 2.19 at the initial period to 7.19 at 8 hrs after meconium instillation. CONCLUSIONS: Our conclusion is that aspiration of meconium causes lung injury in the newborn and that this injury is associated with a significant increase in ET peptide production in the lungs. We also showed that ET production is inhibited by pretreatment of rabbits with captopril before meconium-induced injury. ET-1 and its conversion from ET-1 in response to meconium may play important roles in increasing pulmonary vascular resistance and lung cell death, even in the absence of hypoxia. In general, we conclude, that ET-1 levels are significantly elevated in meconium-instilled rabbits compared with saline-instilled ones, and both can be significantly inhibited by pretreatment with captopril. Whether ET-1 contributes directly to the pathophysiology of or is simply a marker of meconium aspiration syndrome remains speculative." @default.
• W1996861982 created "2016-06-24" @default.
• W1996861982 creator A5011876468 @default.
• W1996861982 creator A5016628233 @default.
• W1996861982 creator A5033223705 @default.
• W1996861982 creator A5036365493 @default.
• W1996861982 creator A5072072941 @default.
• W1996861982 creator A5072822097 @default.
• W1996861982 creator A5082461713 @default.
• W1996861982 date "2002-07-01" @default.
• W1996861982 modified "2023-09-23" @default.
• W1996861982 title "Elevated immunoreactive endothelin-1 levels in newborn rabbit lungs after meconium aspiration." @default.
• W1996861982 cites W1997182477 @default.
• W1996861982 cites W1997324943 @default.
• W1996861982 cites W2010976270 @default.
• W1996861982 cites W2021604241 @default.
• W1996861982 cites W2037162182 @default.
• W1996861982 cites W2061739188 @default.
• W1996861982 cites W2062569346 @default.
• W1996861982 cites W2065925044 @default.
• W1996861982 cites W2076725259 @default.
• W1996861982 cites W2086720313 @default.
• W1996861982 cites W2089269712 @default.
• W1996861982 cites W2092392561 @default.
• W1996861982 cites W2135201623 @default.
• W1996861982 cites W2138302361 @default.
• W1996861982 cites W2162804111 @default.
• W1996861982 doi "https://doi.org/10.1097/01.pcc.0000020393.71041.68" @default.
• W1996861982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12780972" @default.
• W1996861982 hasPublicationYear "2002" @default.
• W1996861982 type Work @default.
• W1996861982 sameAs 1996861982 @default.
• W1996861982 citedByCount "4" @default.
• W1996861982 countsByYear W19968619822019 @default.
• W1996861982 countsByYear W19968619822023 @default.
• W1996861982 crossrefType "journal-article" @default.
• W1996861982 hasAuthorship W1996861982A5011876468 @default.
• W1996861982 hasAuthorship W1996861982A5016628233 @default.
• W1996861982 hasAuthorship W1996861982A5033223705 @default.
• W1996861982 hasAuthorship W1996861982A5036365493 @default.
• W1996861982 hasAuthorship W1996861982A5072072941 @default.
• W1996861982 hasAuthorship W1996861982A5072822097 @default.
• W1996861982 hasAuthorship W1996861982A5082461713 @default.
• W1996861982 hasConcept C126322002 @default.
• W1996861982 hasConcept C144980905 @default.
• W1996861982 hasConcept C170493617 @default.
• W1996861982 hasConcept C172680121 @default.
• W1996861982 hasConcept C2777397205 @default.
• W1996861982 hasConcept C2777714996 @default.
• W1996861982 hasConcept C2779234561 @default.
• W1996861982 hasConcept C2779479957 @default.
• W1996861982 hasConcept C2780745319 @default.
• W1996861982 hasConcept C2780985857 @default.
• W1996861982 hasConcept C42219234 @default.
• W1996861982 hasConcept C54355233 @default.
• W1996861982 hasConcept C71924100 @default.
• W1996861982 hasConcept C84393581 @default.
• W1996861982 hasConcept C86803240 @default.
• W1996861982 hasConceptScore W1996861982C126322002 @default.
• W1996861982 hasConceptScore W1996861982C144980905 @default.
• W1996861982 hasConceptScore W1996861982C170493617 @default.
• W1996861982 hasConceptScore W1996861982C172680121 @default.
• W1996861982 hasConceptScore W1996861982C2777397205 @default.
• W1996861982 hasConceptScore W1996861982C2777714996 @default.
• W1996861982 hasConceptScore W1996861982C2779234561 @default.
• W1996861982 hasConceptScore W1996861982C2779479957 @default.
• W1996861982 hasConceptScore W1996861982C2780745319 @default.
• W1996861982 hasConceptScore W1996861982C2780985857 @default.
• W1996861982 hasConceptScore W1996861982C42219234 @default.
• W1996861982 hasConceptScore W1996861982C54355233 @default.
• W1996861982 hasConceptScore W1996861982C71924100 @default.
• W1996861982 hasConceptScore W1996861982C84393581 @default.
• W1996861982 hasConceptScore W1996861982C86803240 @default.
• W1996861982 hasIssue "3" @default.
• W1996861982 hasLocation W19968619821 @default.
• W1996861982 hasOpenAccess W1996861982 @default.
• W1996861982 hasPrimaryLocation W19968619821 @default.
• W1996861982 hasRelatedWork W1996861982 @default.
• W1996861982 hasRelatedWork W2034182290 @default.
• W1996861982 hasRelatedWork W2053597221 @default.
• W1996861982 hasRelatedWork W2068044834 @default.
• W1996861982 hasRelatedWork W2086911484 @default.
• W1996861982 hasRelatedWork W2093122640 @default.
• W1996861982 hasRelatedWork W2156376323 @default.
• W1996861982 hasRelatedWork W2162102973 @default.
• W1996861982 hasRelatedWork W2356741452 @default.
• W1996861982 hasRelatedWork W2395290536 @default.
• W1996861982 hasVolume "3" @default.
• W1996861982 isParatext "false" @default.
• W1996861982 isRetracted "false" @default.
• W1996861982 magId "1996861982" @default.
• W1996861982 workType "article" @default.