FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996867029> ?p ?o ?g. }

• W1996867029 abstract "Phytosterols have been widely studied for their cholesterol-lowering effect. Conjugated phytosterol forms have been found more active than free moieties. There are no reports about the sterol profile of black bean seed coats neither its effects on cholesterol metabolism. The aim of this research was to identify and quantify phytosterols from black bean seed coats and to determine their effects on cholesterol micellar solubility and on mRNA and key protein levels involved in lipid/cholesterol metabolism and cholesterol transport in primary rat hepatocytes. Free phytosterols, acylated steryl glycosides, and steryl glycosides were extracted from black bean seed coats. They were identified through HPLC-MS-TOF and quantified through HPLC equipped with UV-visible and evaporative light-scattering detectors. Free and conjugated phytosterols from the coats significantly increased the inhibitory effect of cholesterol micelle formation compared with stigmasterol, which was used as control (P < 0.05). In addition, phytosterols of black bean seed coat decreased lipogenesis by the downregulation of lipogenic proteins such as sterol regulatory element-binding protein 1 and fatty acid synthesis (FAS) in primary rat hepatocytes. Regarding β-oxidation, phytosterols upregulated the expression of carnitine palmitoyltransferase I and promoted the β-oxidation of long-chain fatty acids. Phytosterols inhibited cholesterol micellar solubility and reduced the activation of the liver X receptor, decreasing hepatic FAS and promoting hepatic β-oxidation of long-chain fatty acids." @default.
• W1996867029 created "2016-06-24" @default.
• W1996867029 creator A5004535842 @default.
• W1996867029 creator A5007104775 @default.
• W1996867029 creator A5011246919 @default.
• W1996867029 creator A5071365422 @default.
• W1996867029 creator A5086409321 @default.
• W1996867029 date "2013-12-01" @default.
• W1996867029 modified "2023-10-10" @default.
• W1996867029 title "Conjugated and free sterols from black bean (Phaseolus vulgaris L.) seed coats as cholesterol micelle disruptors and their effect on lipid metabolism and cholesterol transport in rat primary hepatocytes" @default.
• W1996867029 cites W1932087083 @default.
• W1996867029 cites W1965789756 @default.
• W1996867029 cites W1966747907 @default.
• W1996867029 cites W1969717498 @default.
• W1996867029 cites W1978639613 @default.
• W1996867029 cites W1980424912 @default.
• W1996867029 cites W1983561739 @default.
• W1996867029 cites W1992958610 @default.
• W1996867029 cites W2005918587 @default.
• W1996867029 cites W2023288622 @default.
• W1996867029 cites W2025093011 @default.
• W1996867029 cites W2031913917 @default.
• W1996867029 cites W2041498503 @default.
• W1996867029 cites W2044237381 @default.
• W1996867029 cites W2049193620 @default.
• W1996867029 cites W2060851254 @default.
• W1996867029 cites W2065249108 @default.
• W1996867029 cites W2067839429 @default.
• W1996867029 cites W2070126347 @default.
• W1996867029 cites W2071897221 @default.
• W1996867029 cites W2072482644 @default.
• W1996867029 cites W2080656797 @default.
• W1996867029 cites W2086792571 @default.
• W1996867029 cites W2107277218 @default.
• W1996867029 cites W2124485866 @default.
• W1996867029 cites W2136823038 @default.
• W1996867029 cites W2139247516 @default.
• W1996867029 cites W2139648578 @default.
• W1996867029 cites W2163431041 @default.
• W1996867029 cites W2329030001 @default.
• W1996867029 cites W2345256582 @default.
• W1996867029 cites W4238251256 @default.
• W1996867029 cites W4251360714 @default.
• W1996867029 cites W4252021281 @default.
• W1996867029 doi "https://doi.org/10.1007/s12263-013-0367-1" @default.
• W1996867029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896614" @default.
• W1996867029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24292989" @default.
• W1996867029 hasPublicationYear "2013" @default.
• W1996867029 type Work @default.
• W1996867029 sameAs 1996867029 @default.
• W1996867029 citedByCount "27" @default.
• W1996867029 countsByYear W19968670292014 @default.
• W1996867029 countsByYear W19968670292015 @default.
• W1996867029 countsByYear W19968670292016 @default.
• W1996867029 countsByYear W19968670292017 @default.
• W1996867029 countsByYear W19968670292018 @default.
• W1996867029 countsByYear W19968670292019 @default.
• W1996867029 countsByYear W19968670292020 @default.
• W1996867029 countsByYear W19968670292021 @default.
• W1996867029 countsByYear W19968670292022 @default.
• W1996867029 countsByYear W19968670292023 @default.
• W1996867029 crossrefType "journal-article" @default.
• W1996867029 hasAuthorship W1996867029A5004535842 @default.
• W1996867029 hasAuthorship W1996867029A5007104775 @default.
• W1996867029 hasAuthorship W1996867029A5011246919 @default.
• W1996867029 hasAuthorship W1996867029A5071365422 @default.
• W1996867029 hasAuthorship W1996867029A5086409321 @default.
• W1996867029 hasBestOaLocation W19968670291 @default.
• W1996867029 hasConcept C185592680 @default.
• W1996867029 hasConcept C2776286235 @default.
• W1996867029 hasConcept C2778016309 @default.
• W1996867029 hasConcept C2778163477 @default.
• W1996867029 hasConcept C2778718757 @default.
• W1996867029 hasConcept C2779718769 @default.
• W1996867029 hasConcept C2781471481 @default.
• W1996867029 hasConcept C31903555 @default.
• W1996867029 hasConcept C43617362 @default.
• W1996867029 hasConcept C4733338 @default.
• W1996867029 hasConcept C543025807 @default.
• W1996867029 hasConcept C55493867 @default.
• W1996867029 hasConcept C59822182 @default.
• W1996867029 hasConcept C62231903 @default.
• W1996867029 hasConcept C86803240 @default.
• W1996867029 hasConceptScore W1996867029C185592680 @default.
• W1996867029 hasConceptScore W1996867029C2776286235 @default.
• W1996867029 hasConceptScore W1996867029C2778016309 @default.
• W1996867029 hasConceptScore W1996867029C2778163477 @default.
• W1996867029 hasConceptScore W1996867029C2778718757 @default.
• W1996867029 hasConceptScore W1996867029C2779718769 @default.
• W1996867029 hasConceptScore W1996867029C2781471481 @default.
• W1996867029 hasConceptScore W1996867029C31903555 @default.
• W1996867029 hasConceptScore W1996867029C43617362 @default.
• W1996867029 hasConceptScore W1996867029C4733338 @default.
• W1996867029 hasConceptScore W1996867029C543025807 @default.
• W1996867029 hasConceptScore W1996867029C55493867 @default.
• W1996867029 hasConceptScore W1996867029C59822182 @default.
• W1996867029 hasConceptScore W1996867029C62231903 @default.
• W1996867029 hasConceptScore W1996867029C86803240 @default.
• W1996867029 hasIssue "1" @default.
• W1996867029 hasLocation W19968670291 @default.

• next