Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996873411> ?p ?o ?g. }
- W1996873411 endingPage "644" @default.
- W1996873411 startingPage "638" @default.
- W1996873411 abstract "Potassium (K+) channels are key regulators of vascular smooth muscle cell (VSMC) excitability. In systemic small arteries, Kv7 channel expression/activity has been noted and a role in vascular tone regulation demonstrated. We aimed to demonstrate functional Kv7 channels in human fetoplacental small arteries. Human placental chorionic plate arteries (CPAs) were obtained at term. CPA responses to Kv7 channel modulators was determined by wire myography. Presence of Kv7 channel mRNA (encoded by KCNQ1-5) and protein expression were assessed by RT-PCR and immunohistochemistry/immunofluorescence, respectively. Kv7 channel blockade with linopirdine increased CPA basal tone and AVP-induced contraction. Pre-contracted CPAs (AVP; 80 mM K+ depolarization solution) exhibited significant relaxation to flupirtine, retigabine, the acrylamide (S)-1, and (S) BMS-204352, differential activators of Kv7.1 – Kv7.5 channels. All CPAs assessed expressed KCNQ1 and KCNQ3-5 mRNA; KCNQ2 was expressed only in a subset of CPAs. Kv7 protein expression was confirmed in intact CPAs and isolated VSMCs. Kv7 channels are present and active in fetoplacental vessels, contributing to vascular tone regulation in normal pregnancy. Targeting these channels may represent a therapeutic intervention in pregnancies complicated by increased vascular resistance." @default.
- W1996873411 created "2016-06-24" @default.
- W1996873411 creator A5010577194 @default.
- W1996873411 creator A5011623909 @default.
- W1996873411 creator A5013641853 @default.
- W1996873411 creator A5016387969 @default.
- W1996873411 creator A5018127379 @default.
- W1996873411 creator A5040137207 @default.
- W1996873411 creator A5041426510 @default.
- W1996873411 creator A5047461062 @default.
- W1996873411 creator A5072464610 @default.
- W1996873411 creator A5079633045 @default.
- W1996873411 creator A5087102130 @default.
- W1996873411 creator A5089206203 @default.
- W1996873411 date "2015-06-01" @default.
- W1996873411 modified "2023-10-15" @default.
- W1996873411 title "Activation of K V 7 channels stimulates vasodilatation of human placental chorionic plate arteries" @default.
- W1996873411 cites W1603834177 @default.
- W1996873411 cites W1753089048 @default.
- W1996873411 cites W1780476192 @default.
- W1996873411 cites W1971447438 @default.
- W1996873411 cites W1979543489 @default.
- W1996873411 cites W1987772277 @default.
- W1996873411 cites W1993615180 @default.
- W1996873411 cites W2008066000 @default.
- W1996873411 cites W2017590643 @default.
- W1996873411 cites W2021225492 @default.
- W1996873411 cites W2021739695 @default.
- W1996873411 cites W2024733121 @default.
- W1996873411 cites W2031537116 @default.
- W1996873411 cites W2042101507 @default.
- W1996873411 cites W2047069083 @default.
- W1996873411 cites W2082133283 @default.
- W1996873411 cites W2086391194 @default.
- W1996873411 cites W2098714915 @default.
- W1996873411 cites W2099437428 @default.
- W1996873411 cites W2101884847 @default.
- W1996873411 cites W2102115309 @default.
- W1996873411 cites W2105397162 @default.
- W1996873411 cites W2105807298 @default.
- W1996873411 cites W2106926346 @default.
- W1996873411 cites W2113316512 @default.
- W1996873411 cites W2114685731 @default.
- W1996873411 cites W2127461430 @default.
- W1996873411 cites W2130379248 @default.
- W1996873411 cites W2137263523 @default.
- W1996873411 cites W2139199076 @default.
- W1996873411 cites W2144590281 @default.
- W1996873411 cites W2148583712 @default.
- W1996873411 cites W2151155358 @default.
- W1996873411 cites W2157624459 @default.
- W1996873411 cites W2159911721 @default.
- W1996873411 cites W2168858520 @default.
- W1996873411 cites W3339244 @default.
- W1996873411 cites W4245386513 @default.
- W1996873411 cites W2059811150 @default.
- W1996873411 doi "https://doi.org/10.1016/j.placenta.2015.03.007" @default.
- W1996873411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25862611" @default.
- W1996873411 hasPublicationYear "2015" @default.
- W1996873411 type Work @default.
- W1996873411 sameAs 1996873411 @default.
- W1996873411 citedByCount "17" @default.
- W1996873411 countsByYear W19968734112016 @default.
- W1996873411 countsByYear W19968734112018 @default.
- W1996873411 countsByYear W19968734112019 @default.
- W1996873411 countsByYear W19968734112020 @default.
- W1996873411 countsByYear W19968734112021 @default.
- W1996873411 countsByYear W19968734112022 @default.
- W1996873411 countsByYear W19968734112023 @default.
- W1996873411 crossrefType "journal-article" @default.
- W1996873411 hasAuthorship W1996873411A5010577194 @default.
- W1996873411 hasAuthorship W1996873411A5011623909 @default.
- W1996873411 hasAuthorship W1996873411A5013641853 @default.
- W1996873411 hasAuthorship W1996873411A5016387969 @default.
- W1996873411 hasAuthorship W1996873411A5018127379 @default.
- W1996873411 hasAuthorship W1996873411A5040137207 @default.
- W1996873411 hasAuthorship W1996873411A5041426510 @default.
- W1996873411 hasAuthorship W1996873411A5047461062 @default.
- W1996873411 hasAuthorship W1996873411A5072464610 @default.
- W1996873411 hasAuthorship W1996873411A5079633045 @default.
- W1996873411 hasAuthorship W1996873411A5087102130 @default.
- W1996873411 hasAuthorship W1996873411A5089206203 @default.
- W1996873411 hasConcept C120770815 @default.
- W1996873411 hasConcept C126322002 @default.
- W1996873411 hasConcept C134018914 @default.
- W1996873411 hasConcept C172680121 @default.
- W1996873411 hasConcept C1918360 @default.
- W1996873411 hasConcept C2776952824 @default.
- W1996873411 hasConcept C2776953305 @default.
- W1996873411 hasConcept C2778457506 @default.
- W1996873411 hasConcept C2779234561 @default.
- W1996873411 hasConcept C2779395532 @default.
- W1996873411 hasConcept C2779941686 @default.
- W1996873411 hasConcept C2992686903 @default.
- W1996873411 hasConcept C54355233 @default.
- W1996873411 hasConcept C71924100 @default.
- W1996873411 hasConcept C83743174 @default.
- W1996873411 hasConcept C86803240 @default.