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- W1996881736 abstract "The luteinizing releasing hormone (LRH or pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) has been usefully synthesized by coupling the unprotected hexapeptide and tetrapeptide, pGlu-His-Trp-Ser-Tyr-Gly-OH and Leu-Arg-Pro-Gly-NH2. This new versatile synthesis also conveniently provides analogs with changes in the 7-10-positions. Possible conformations of parallel planarity of Trp- and Tyr-, and significance of the guanidino group for activity and potency of LRH led to synthesis of His8-LRH, Nva8-LRH and Des-Arg8-LRH. Activities indicate a participating ionic mechanism for release and potency due to a basic moiety in the 8-position. Data on Nva8-LRH and Des-Arg8-LRH seem to support concepts of conformation and basicity." @default.
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- W1996881736 date "1972-05-01" @default.
- W1996881736 modified "2023-09-25" @default.
- W1996881736 title "Luteinizing releasing hormone, synthesis and ARG8-analogs, and conformation-sequence-activity relationships" @default.
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- W1996881736 doi "https://doi.org/10.1016/0006-291x(72)90552-9" @default.
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