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- W1996882425 abstract "The contraction of the rat uterus and gerbil colon to prostaglandins E1, E2, F1α and F2α and the modification of ADP-induced platelet aggregation by PGE1 and PGE2 is inhibited by prior treatment with 1, 4-dithiothreitol (DTT) or with p-hydroxymercuribenzoate (PHMB). The inhibition by both reagents is characterized by an increase in the concentration of prostaglandin needed to elicit half-maximal and maximal responses. The inhibition due to PHMB is reversed by subsequent treatment with thiol compounds whereas, in the case of DTT, oxidising agents are required. N-ethylmaleimide (NEM) prevents the reversal of DTT inhibition by the oxidising agent 5,5′-dithiobis-(2-nitrobenzoate). The effect of DTT is attentuated by the presence of prostaglandin or 7-oxa-13-prostynoic acid, a competitive antagonist for prostaglandins, suggesting protection of those disulfide groups specifically associated with prostaglandin action. It is concluded that dithiothreitol reduces disulfide groups and that PHMB complexes with sulfhydryl groups in the vicinity of one or more components of the prostaglandin receptor." @default.
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- W1996882425 date "1974-01-01" @default.
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- W1996882425 title "The significance of protein disulfide and sulfhydryl groups in prostaglandin action" @default.
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- W1996882425 doi "https://doi.org/10.1016/s0090-6980(74)80104-8" @default.
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