Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996907537> ?p ?o ?g. }
- W1996907537 endingPage "76" @default.
- W1996907537 startingPage "68" @default.
- W1996907537 abstract "A group of structurally related drugs representing diverse therapeutic classes share, among a number of pharmacological properties, enhancement of tumor growth in several rodent models of malignancy. One common action, the inhibition of histamine binding to and catalytic activity of cytochrome P450 monooxygenases, is highly correlated with potency to enhance tumor growth. Among members of this drug ensemble, the antiestrogen tamoxifen has been shown in controlled clinical studies to increase the incidence of uterine and gastrointestinal cancer and to accelerate the course of gastric cancer, and the tamoxifen analogue clomiphene has been linked to neuroblastoma and the tricyclic group of antidepressants to ovarian cancer. The determination of drug affinities for protein modulators of cell growth, proliferation, and transformation suggests a strategy for identifying at least some classes of chemicals that impart oncologic risks to humans. © 1996 Wiley-Liss, Inc." @default.
- W1996907537 created "2016-06-24" @default.
- W1996907537 creator A5000036994 @default.
- W1996907537 creator A5091553175 @default.
- W1996907537 date "1996-06-01" @default.
- W1996907537 modified "2023-09-27" @default.
- W1996907537 title "Enhancement of tumor growth by drugs with some common molecular actions" @default.
- W1996907537 cites W1145598662 @default.
- W1996907537 cites W1515379766 @default.
- W1996907537 cites W1714294326 @default.
- W1996907537 cites W1964813535 @default.
- W1996907537 cites W1968197133 @default.
- W1996907537 cites W1972602003 @default.
- W1996907537 cites W1973158453 @default.
- W1996907537 cites W1974350281 @default.
- W1996907537 cites W1975418744 @default.
- W1996907537 cites W1978344058 @default.
- W1996907537 cites W1984333931 @default.
- W1996907537 cites W1987260756 @default.
- W1996907537 cites W1988096609 @default.
- W1996907537 cites W1993173503 @default.
- W1996907537 cites W1995131196 @default.
- W1996907537 cites W1996684892 @default.
- W1996907537 cites W2001204924 @default.
- W1996907537 cites W2003323069 @default.
- W1996907537 cites W2005131700 @default.
- W1996907537 cites W2007842184 @default.
- W1996907537 cites W2008982161 @default.
- W1996907537 cites W2009907090 @default.
- W1996907537 cites W2009983407 @default.
- W1996907537 cites W2010637981 @default.
- W1996907537 cites W2012212858 @default.
- W1996907537 cites W2013673956 @default.
- W1996907537 cites W2016382271 @default.
- W1996907537 cites W2016391200 @default.
- W1996907537 cites W2020815103 @default.
- W1996907537 cites W2021494550 @default.
- W1996907537 cites W2031224760 @default.
- W1996907537 cites W2031772071 @default.
- W1996907537 cites W2032899019 @default.
- W1996907537 cites W2037006831 @default.
- W1996907537 cites W2038662781 @default.
- W1996907537 cites W2038768143 @default.
- W1996907537 cites W2039420718 @default.
- W1996907537 cites W2039734065 @default.
- W1996907537 cites W2041077907 @default.
- W1996907537 cites W2041779532 @default.
- W1996907537 cites W2047637104 @default.
- W1996907537 cites W2048963964 @default.
- W1996907537 cites W2052433908 @default.
- W1996907537 cites W2054532717 @default.
- W1996907537 cites W2056101835 @default.
- W1996907537 cites W2060855916 @default.
- W1996907537 cites W2062795632 @default.
- W1996907537 cites W2071541326 @default.
- W1996907537 cites W2076336558 @default.
- W1996907537 cites W2078271499 @default.
- W1996907537 cites W2082218494 @default.
- W1996907537 cites W2087354062 @default.
- W1996907537 cites W2088914856 @default.
- W1996907537 cites W2091327765 @default.
- W1996907537 cites W2093040718 @default.
- W1996907537 cites W2094974099 @default.
- W1996907537 cites W2097548418 @default.
- W1996907537 cites W2101026512 @default.
- W1996907537 cites W2102775263 @default.
- W1996907537 cites W2123904827 @default.
- W1996907537 cites W2131894174 @default.
- W1996907537 cites W2144641232 @default.
- W1996907537 cites W2149944230 @default.
- W1996907537 cites W2159877590 @default.
- W1996907537 cites W2408788254 @default.
- W1996907537 cites W4293281579 @default.
- W1996907537 cites W1999531707 @default.
- W1996907537 doi "https://doi.org/10.1002/(sici)1098-2744(199606)16:2<68::aid-mc2>3.0.co;2-j" @default.
- W1996907537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8645428" @default.
- W1996907537 hasPublicationYear "1996" @default.
- W1996907537 type Work @default.
- W1996907537 sameAs 1996907537 @default.
- W1996907537 citedByCount "22" @default.
- W1996907537 countsByYear W19969075372013 @default.
- W1996907537 crossrefType "journal-article" @default.
- W1996907537 hasAuthorship W1996907537A5000036994 @default.
- W1996907537 hasAuthorship W1996907537A5091553175 @default.
- W1996907537 hasConcept C121608353 @default.
- W1996907537 hasConcept C2776067312 @default.
- W1996907537 hasConcept C2777176818 @default.
- W1996907537 hasConcept C2779399171 @default.
- W1996907537 hasConcept C2780035454 @default.
- W1996907537 hasConcept C2780427987 @default.
- W1996907537 hasConcept C502942594 @default.
- W1996907537 hasConcept C530470458 @default.
- W1996907537 hasConcept C54355233 @default.
- W1996907537 hasConcept C56173144 @default.
- W1996907537 hasConcept C60644358 @default.
- W1996907537 hasConcept C86803240 @default.
- W1996907537 hasConcept C98274493 @default.
- W1996907537 hasConceptScore W1996907537C121608353 @default.