FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996919323> ?p ?o ?g. }

• W1996919323 endingPage "3986" @default.
• W1996919323 startingPage "3981" @default.
• W1996919323 abstract "Purpose Lynch syndrome is associated with inherited germline mutations in mismatch repair (MMR) genes. Genetic testing in high-risk individuals may yield indeterminate results if no mutation is found or if a mutation of unclear pathogenic significance is observed. There are limited data regarding how well patients with Lynch syndrome understand the clinical implications of genetic test results. This study examines colorectal cancer (CRC) risk perception in individuals tested for MMR mutations and identifies the factors associated with an appropriate interpretation of their cancer risk. Patients and Methods A total of 159 individuals who met the Revised Bethesda Guidelines and had previously undergone genetic testing completed a questionnaire eliciting demographic data, cancer history, genetic test results, and an estimate of their CRC risk. Associations between clinical factors, genetic test results, and CRC risk perception were explored using multivariable analyses. Results Of the 100 individuals with a pathogenic mutation (true positive), 90 (90%) correctly estimated their CRC risk as “high” or “very high” compared with other individuals their age. However, only 23 (62%) of 37 individuals with an indeterminate genetic test result correctly estimated their risk. Individuals with a history of Lynch syndrome–associated cancer (odds ratio [OR], 0.1; 95% CI, 0.1 to 0.6) or indeterminate genetic test results (OR, 0.2; 95% CI, 0.1 to 0.6) were significantly less likely to estimate their CRC risk as increased. Conclusion Patients at risk for Lynch syndrome with an indeterminate genetic test result may be falsely reassured. It is important that health care providers continue to discuss the implications of uninformative results on lifetime cancer risk." @default.
• W1996919323 created "2016-06-24" @default.
• W1996919323 creator A5014535384 @default.
• W1996919323 creator A5019349024 @default.
• W1996919323 creator A5021274309 @default.
• W1996919323 creator A5034385567 @default.
• W1996919323 creator A5036424363 @default.
• W1996919323 creator A5038045975 @default.
• W1996919323 creator A5045679608 @default.
• W1996919323 creator A5050037868 @default.
• W1996919323 creator A5070703103 @default.
• W1996919323 creator A5077932572 @default.
• W1996919323 creator A5079620607 @default.
• W1996919323 creator A5086897381 @default.
• W1996919323 date "2009-08-20" @default.
• W1996919323 modified "2023-09-30" @default.
• W1996919323 title "Colorectal Cancer Risk Perception on the Basis of Genetic Test Results in Individuals at Risk for Lynch Syndrome" @default.
• W1996919323 cites W1963802150 @default.
• W1996919323 cites W2010053675 @default.
• W1996919323 cites W2021303737 @default.
• W1996919323 cites W2032431216 @default.
• W1996919323 cites W2033193225 @default.
• W1996919323 cites W2040438137 @default.
• W1996919323 cites W2045666244 @default.
• W1996919323 cites W2071246752 @default.
• W1996919323 cites W2100880689 @default.
• W1996919323 cites W2119674333 @default.
• W1996919323 cites W2124561249 @default.
• W1996919323 cites W2128394231 @default.
• W1996919323 cites W2128793721 @default.
• W1996919323 cites W2132666634 @default.
• W1996919323 cites W2145828336 @default.
• W1996919323 cites W2146394496 @default.
• W1996919323 cites W2156299764 @default.
• W1996919323 cites W2157420579 @default.
• W1996919323 cites W2161076410 @default.
• W1996919323 cites W2165594662 @default.
• W1996919323 cites W2166601685 @default.
• W1996919323 cites W2181086016 @default.
• W1996919323 cites W31254998 @default.
• W1996919323 cites W4241726394 @default.
• W1996919323 cites W4297625496 @default.
• W1996919323 cites W2073529199 @default.
• W1996919323 doi "https://doi.org/10.1200/jco.2008.18.6940" @default.
• W1996919323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2734398" @default.
• W1996919323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19620492" @default.
• W1996919323 hasPublicationYear "2009" @default.
• W1996919323 type Work @default.
• W1996919323 sameAs 1996919323 @default.
• W1996919323 citedByCount "21" @default.
• W1996919323 countsByYear W19969193232012 @default.
• W1996919323 countsByYear W19969193232013 @default.
• W1996919323 countsByYear W19969193232014 @default.
• W1996919323 countsByYear W19969193232016 @default.
• W1996919323 countsByYear W19969193232017 @default.
• W1996919323 countsByYear W19969193232018 @default.
• W1996919323 countsByYear W19969193232019 @default.
• W1996919323 countsByYear W19969193232022 @default.
• W1996919323 crossrefType "journal-article" @default.
• W1996919323 hasAuthorship W1996919323A5014535384 @default.
• W1996919323 hasAuthorship W1996919323A5019349024 @default.
• W1996919323 hasAuthorship W1996919323A5021274309 @default.
• W1996919323 hasAuthorship W1996919323A5034385567 @default.
• W1996919323 hasAuthorship W1996919323A5036424363 @default.
• W1996919323 hasAuthorship W1996919323A5038045975 @default.
• W1996919323 hasAuthorship W1996919323A5045679608 @default.
• W1996919323 hasAuthorship W1996919323A5050037868 @default.
• W1996919323 hasAuthorship W1996919323A5070703103 @default.
• W1996919323 hasAuthorship W1996919323A5077932572 @default.
• W1996919323 hasAuthorship W1996919323A5079620607 @default.
• W1996919323 hasAuthorship W1996919323A5086897381 @default.
• W1996919323 hasBestOaLocation W19969193232 @default.
• W1996919323 hasConcept C121608353 @default.
• W1996919323 hasConcept C126322002 @default.
• W1996919323 hasConcept C143998085 @default.
• W1996919323 hasConcept C156957248 @default.
• W1996919323 hasConcept C2776559941 @default.
• W1996919323 hasConcept C2780673598 @default.
• W1996919323 hasConcept C2781179581 @default.
• W1996919323 hasConcept C526805850 @default.
• W1996919323 hasConcept C54355233 @default.
• W1996919323 hasConcept C60748783 @default.
• W1996919323 hasConcept C71924100 @default.
• W1996919323 hasConcept C80227256 @default.
• W1996919323 hasConcept C86803240 @default.
• W1996919323 hasConceptScore W1996919323C121608353 @default.
• W1996919323 hasConceptScore W1996919323C126322002 @default.
• W1996919323 hasConceptScore W1996919323C143998085 @default.
• W1996919323 hasConceptScore W1996919323C156957248 @default.
• W1996919323 hasConceptScore W1996919323C2776559941 @default.
• W1996919323 hasConceptScore W1996919323C2780673598 @default.
• W1996919323 hasConceptScore W1996919323C2781179581 @default.
• W1996919323 hasConceptScore W1996919323C526805850 @default.
• W1996919323 hasConceptScore W1996919323C54355233 @default.
• W1996919323 hasConceptScore W1996919323C60748783 @default.
• W1996919323 hasConceptScore W1996919323C71924100 @default.
• W1996919323 hasConceptScore W1996919323C80227256 @default.
• W1996919323 hasConceptScore W1996919323C86803240 @default.

• next