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- W1996920525 abstract "Patients (n = 1,392) admitted to the intensive-care unit were randomized to receive either 100 mg/kg intravenous immune globulin (IVIG) hyperimmune to Klebsiella spp. and Pseudomonas aeruginosa or an albumin placebo. There was no difference in the overall mortality rates between the two groups. The incidences of infections due to Klebsiella spp. and gram-positive bacteria were reduced in the IVIG group. The incidence of P. aeruginosa infections was not affected. Administration of IVIG completely prevented Klebsiella bacteremia and reduced the incidence of severe Klebsiella infections. Patients receiving IVIG had a higher incidence of adverse reactions than the placebo group. There was a trend towards a reduced infection rate for both Klebsiella spp. and P. aeruginosa with increasing specific-antibody levels. Therefore, a second trial has been initiated in which the dose of IVIG has been increased to 300 mg/kg." @default.
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- W1996920525 date "1996-01-01" @default.
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- W1996920525 title "Immunoprophylaxis against Bacterial Infection in the Intensive-Care Unit" @default.
- W1996920525 doi "https://doi.org/10.1159/000172480" @default.
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