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- W1996924892 abstract "ISEE-0756 Background and Objective: Air pollution effects on children’s neurodevelopment have recently been assessed. However, these studies are based on small samples. Our study aims to assess the effects of traffic-related air pollution exposure during pregnancy in children’s neurodevelopment at 14 months. Methods: In the Spanish INMA (Environment and Childhood)-Sabadell birth cohort, 657 women were recruited during the 1st trimester of pregnancy. NO2 and benzene, toluene, ethylbenzene, m, p-xylene and o-xylene (BTEX) were measured at 57 sampling sites with passive samplers between April 2005 and March 2006. Land-use regression (LUR) models were developed for each pollutant using geographic data as predictor variables and then applied to predict outdoor air pollution levels at each cohort address. LUR estimates were temporally-adjusted using daily levels of NO2 measured at a fixed monitor. For 520 pregnant women we obtained 9-month average exposures as well as trimester specific exposures for each pollutant. Information on parental socio-demographic characteristics, occupational history, and life-style was obtained by questionnaire. At 14 months, mental and psychomotor development with Bayley Scales of Infant Development was assessed. Multivariable linear regression models were performed. Results: Exposure during pregnancy ranged from 17.6 to 66.7 μg/m3 for NO2 and from 3.0 to 29.5 μg/m3 for BTEX. Among the different periods of exposure, exposure of both pollutants only during the 3rd trimester of pregnancy showed a negative association with mental development score, although not statistically significant (β = −0.24, 95% confidence interval: −1.49, 0.97 and β = −0.37, 95% confidence interval: −2.42, 1.69 for each increase in 10 μg/m3 of NO2 and BTEX, respectively). Conclusion: We did not find an effect of exposure to NO2 and BTEX during pregnancy on children’s neurodevelopment at 14 months. This lack of significant findings at an early age suggests that prenatal exposure to air pollution could have undetectable effects when general cognition is starting to be conformed." @default.
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- W1996924892 date "2009-11-01" @default.
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- W1996924892 title "GIS-Based Exposure to Traffic-Related Air Pollution During Pregnancy and Neurodevelopment at 14 Months" @default.
- W1996924892 doi "https://doi.org/10.1097/01.ede.0000362697.67328.10" @default.
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