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• W1996925248 abstract "The objective of this study was to determine if exogenous surfactant therapy could prevent the harmful effects of ventilation at high tidal volumes without positive end-expiratory pressure (PEEP). Rats were randomized to either a nontreated control group (8 mL/kg 4 cm H2O PEEP), a nontreated injuriously ventilated group (20 mL/kg 0 cm H2O PEEP) or a treatment group of either 50 mg/kg, 50 mg/kg + 5% surfactant-associated protein A, 100 mg/kg exogenous surfactant followed by injurious ventilation. Isolated lungs from animals in all 5 groups were ventilated in a humidified box at 37 degrees C for 2 hours. Pressure-volume curves and light microscopy showed that surfactant treatment reduced the ventilation-induced lung injury (VILI). Inflammatory cytokines (tumor necrosis factor-alpha [TNFalpha], interleukin [IL]-1beta, and IL-6) in the lavage were significantly higher in injuriously ventilated lungs compared to the control group. However the 3 treatment groups had cytokine concentrations that were similar to the injuriously ventilated group. We conclude that surfactant treatment is beneficial in preventing VILI; however, it does not prevent the release of inrflammatory cytokines during mechanical ventilation." @default.
• W1996925248 created "2016-06-24" @default.
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• W1996925248 date "2001-01-01" @default.
• W1996925248 modified "2023-09-27" @default.
• W1996925248 title "SURFACTANT TREATMENT FOR VENTILATION-INDUCED LUNG INJURY IN RATS: EFFECTS ON LUNG COMPLIANCE AND CYTOKINES" @default.
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• W1996925248 doi "https://doi.org/10.1080/019021401750414038" @default.
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