FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996934204> ?p ?o ?g. }

• W1996934204 endingPage "247" @default.
• W1996934204 startingPage "235" @default.
• W1996934204 abstract "The relationship between the apparently random chromosomal changes found in aneuploidy and the genetic instability driving the progression of cancer is not clear. We report a test of the hypothesis that aneuploid chromosomal abnormalities might be selected to preserve cell-survival genes during loss of heterozygosity (LOH) formations which eliminate tumor suppressor genes. The LOHs and structurally abnormal chromosomes present in the aneuploid LoVo (colon), A549 (lung), SUIT-2 (pancreas), and LN-18 (glioma) cancer cell lines were identified by single nucleotide polymorphisms (SNPs) and Spectral Karyotyping (SKY). The Mann-Whitney U and chi square tests were used to evaluate possible differences in chromosome numbers and abnormalities between the cell lines, with two-tailed P values of <0.01 being considered significant. The cell lines differed significantly in chromosome numbers and frequency of structurally abnormal chromosomes. The SNP analysis revealed that each cell line contained at least a haploid set of somatic chromosomes, consistent with our hypothesis that cell-survival genes are widely scattered throughout the genome. Further, over 90% of the chromosomal abnormalities seemed to be selected, often after LOH formation, for gene-dosage compensation or to provide heterozygosity for specific chromosomal regions. These results suggest that the chromosomal changes of aneuploidy are not random, but may be selected to provide gene-dosage compensation and/or retain functional alleles of cell-survival genes during LOH formation." @default.
• W1996934204 created "2016-06-24" @default.
• W1996934204 creator A5049704583 @default.
• W1996934204 creator A5051810494 @default.
• W1996934204 creator A5062403815 @default.
• W1996934204 creator A5072240187 @default.
• W1996934204 date "2007-01-01" @default.
• W1996934204 modified "2023-09-23" @default.
• W1996934204 title "A model for genetic complementation controlling the chromosomal abnormalities and loss of heterozygosity formation in cancer" @default.
• W1996934204 cites W1022338134 @default.
• W1996934204 cites W1965520865 @default.
• W1996934204 cites W1967304777 @default.
• W1996934204 cites W1968888540 @default.
• W1996934204 cites W1972621484 @default.
• W1996934204 cites W1987229185 @default.
• W1996934204 cites W1994016382 @default.
• W1996934204 cites W1999389908 @default.
• W1996934204 cites W2005472812 @default.
• W1996934204 cites W2007321429 @default.
• W1996934204 cites W2015584001 @default.
• W1996934204 cites W2017768095 @default.
• W1996934204 cites W2022527641 @default.
• W1996934204 cites W2024394266 @default.
• W1996934204 cites W2034343209 @default.
• W1996934204 cites W2038987332 @default.
• W1996934204 cites W2042903453 @default.
• W1996934204 cites W2054547280 @default.
• W1996934204 cites W2059090231 @default.
• W1996934204 cites W2059934507 @default.
• W1996934204 cites W2060067137 @default.
• W1996934204 cites W2069601865 @default.
• W1996934204 cites W2075522151 @default.
• W1996934204 cites W2080308138 @default.
• W1996934204 cites W2091812550 @default.
• W1996934204 cites W2108376581 @default.
• W1996934204 cites W2115802074 @default.
• W1996934204 cites W2123820544 @default.
• W1996934204 cites W2127742700 @default.
• W1996934204 cites W2130813854 @default.
• W1996934204 cites W2146464537 @default.
• W1996934204 cites W2148968791 @default.
• W1996934204 cites W2328982008 @default.
• W1996934204 cites W2333922622 @default.
• W1996934204 doi "https://doi.org/10.1159/000100406" @default.
• W1996934204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17431320" @default.
• W1996934204 hasPublicationYear "2007" @default.
• W1996934204 type Work @default.
• W1996934204 sameAs 1996934204 @default.
• W1996934204 citedByCount "7" @default.
• W1996934204 countsByYear W19969342042012 @default.
• W1996934204 countsByYear W19969342042013 @default.
• W1996934204 countsByYear W19969342042017 @default.
• W1996934204 crossrefType "journal-article" @default.
• W1996934204 hasAuthorship W1996934204A5049704583 @default.
• W1996934204 hasAuthorship W1996934204A5051810494 @default.
• W1996934204 hasAuthorship W1996934204A5062403815 @default.
• W1996934204 hasAuthorship W1996934204A5072240187 @default.
• W1996934204 hasConcept C104317684 @default.
• W1996934204 hasConcept C121608353 @default.
• W1996934204 hasConcept C127764415 @default.
• W1996934204 hasConcept C138626823 @default.
• W1996934204 hasConcept C140752955 @default.
• W1996934204 hasConcept C143191323 @default.
• W1996934204 hasConcept C143589142 @default.
• W1996934204 hasConcept C153911025 @default.
• W1996934204 hasConcept C180754005 @default.
• W1996934204 hasConcept C2778264664 @default.
• W1996934204 hasConcept C2779672484 @default.
• W1996934204 hasConcept C2780646079 @default.
• W1996934204 hasConcept C30481170 @default.
• W1996934204 hasConcept C53226629 @default.
• W1996934204 hasConcept C54355233 @default.
• W1996934204 hasConcept C555283112 @default.
• W1996934204 hasConcept C86803240 @default.
• W1996934204 hasConceptScore W1996934204C104317684 @default.
• W1996934204 hasConceptScore W1996934204C121608353 @default.
• W1996934204 hasConceptScore W1996934204C127764415 @default.
• W1996934204 hasConceptScore W1996934204C138626823 @default.
• W1996934204 hasConceptScore W1996934204C140752955 @default.
• W1996934204 hasConceptScore W1996934204C143191323 @default.
• W1996934204 hasConceptScore W1996934204C143589142 @default.
• W1996934204 hasConceptScore W1996934204C153911025 @default.
• W1996934204 hasConceptScore W1996934204C180754005 @default.
• W1996934204 hasConceptScore W1996934204C2778264664 @default.
• W1996934204 hasConceptScore W1996934204C2779672484 @default.
• W1996934204 hasConceptScore W1996934204C2780646079 @default.
• W1996934204 hasConceptScore W1996934204C30481170 @default.
• W1996934204 hasConceptScore W1996934204C53226629 @default.
• W1996934204 hasConceptScore W1996934204C54355233 @default.
• W1996934204 hasConceptScore W1996934204C555283112 @default.
• W1996934204 hasConceptScore W1996934204C86803240 @default.
• W1996934204 hasIssue "4" @default.
• W1996934204 hasLocation W19969342041 @default.
• W1996934204 hasLocation W19969342042 @default.
• W1996934204 hasOpenAccess W1996934204 @default.
• W1996934204 hasPrimaryLocation W19969342041 @default.
• W1996934204 hasRelatedWork W1488193995 @default.
• W1996934204 hasRelatedWork W1817623438 @default.

• next