FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996934880> ?p ?o ?g. }

• W1996934880 endingPage "1669" @default.
• W1996934880 startingPage "1657" @default.
• W1996934880 abstract "Gliomas have been termed recurrent cancers due to their highly aggressive nature. Their tendency to infiltrate and metastasize has posed significant roadblocks to in attaining fool proof treatment solutions. An initiative to curb such a scenario was successfully demonstrated in vitro, utilizing a multi-conceptual gold nanoparticle based photo-thermal and drug combination therapy. Gold nanoparticles (Au NPs) were synthesized with a highly environmentally benign process. The Au NPs were PEGylated and conjugated with folate and transferrin antibody to achieve a dual targeted nano-formulation directed towards gliomas. Curcin, a type 1 ribosome inactivating protein, was attached to the Au NPs as the drug candidate, and its multifarious toxic aspects analyzed in vitro. NIR photo-thermal properties of the Au nano-conjugates were studied to selectively ablate the glioma cancer colonies. Highly cyto-compatible, 10–15 nm Au NP conjugates were synthesized with pronounced specificity towards gliomas. Curcin was successfully conjugated to the Au NPs with pH responsive drug release. Prominent toxic aspects of curcin, such as ROS generation, mitochondrial and cytoskeletal destabilization were witnessed. Excellent photo-thermal ablation properties of gold nanoparticles were utilized to completely disrupt the cancer colonies with significant precision. The multifunctional nanoconjugate projects its competence in imparting complete arrest of the future proliferation or migration of the cancer mass. With multifunctionality the essence of nanomedicine in recent years, the present nanoconjugate highlights itself as a viable option for a multimodal treatment option for brain cancers and the like." @default.
• W1996934880 created "2016-06-24" @default.
• W1996934880 creator A5017898982 @default.
• W1996934880 creator A5019004714 @default.
• W1996934880 creator A5023502084 @default.
• W1996934880 creator A5024410377 @default.
• W1996934880 creator A5027781711 @default.
• W1996934880 creator A5033191945 @default.
• W1996934880 creator A5064129181 @default.
• W1996934880 creator A5064917774 @default.
• W1996934880 date "2014-06-01" @default.
• W1996934880 modified "2023-10-16" @default.
• W1996934880 title "Type 1 ribotoxin-curcin conjugated biogenic gold nanoparticles for a multimodal therapeutic approach towards brain cancer" @default.
• W1996934880 cites W1963797031 @default.
• W1996934880 cites W1968112618 @default.
• W1996934880 cites W1975750363 @default.
• W1996934880 cites W1983596157 @default.
• W1996934880 cites W1986714589 @default.
• W1996934880 cites W1990474062 @default.
• W1996934880 cites W1996262658 @default.
• W1996934880 cites W1998466442 @default.
• W1996934880 cites W1999820009 @default.
• W1996934880 cites W2003897392 @default.
• W1996934880 cites W2004967542 @default.
• W1996934880 cites W2015230924 @default.
• W1996934880 cites W2015540146 @default.
• W1996934880 cites W2018484218 @default.
• W1996934880 cites W2032760352 @default.
• W1996934880 cites W2050819735 @default.
• W1996934880 cites W2053466472 @default.
• W1996934880 cites W2054434888 @default.
• W1996934880 cites W2055944585 @default.
• W1996934880 cites W2057627496 @default.
• W1996934880 cites W2065691617 @default.
• W1996934880 cites W2077228161 @default.
• W1996934880 cites W2077348336 @default.
• W1996934880 cites W2080034820 @default.
• W1996934880 cites W2080113462 @default.
• W1996934880 cites W2088754604 @default.
• W1996934880 cites W2089294693 @default.
• W1996934880 cites W2092666165 @default.
• W1996934880 cites W2106739895 @default.
• W1996934880 cites W2107914421 @default.
• W1996934880 cites W2111115146 @default.
• W1996934880 cites W2135036956 @default.
• W1996934880 cites W2152885242 @default.
• W1996934880 cites W2159594070 @default.
• W1996934880 cites W2167697487 @default.
• W1996934880 cites W2318824598 @default.
• W1996934880 cites W2325240074 @default.
• W1996934880 doi "https://doi.org/10.1016/j.bbagen.2013.12.020" @default.
• W1996934880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24361614" @default.
• W1996934880 hasPublicationYear "2014" @default.
• W1996934880 type Work @default.
• W1996934880 sameAs 1996934880 @default.
• W1996934880 citedByCount "44" @default.
• W1996934880 countsByYear W19969348802014 @default.
• W1996934880 countsByYear W19969348802015 @default.
• W1996934880 countsByYear W19969348802016 @default.
• W1996934880 countsByYear W19969348802017 @default.
• W1996934880 countsByYear W19969348802018 @default.
• W1996934880 countsByYear W19969348802019 @default.
• W1996934880 countsByYear W19969348802020 @default.
• W1996934880 countsByYear W19969348802021 @default.
• W1996934880 countsByYear W19969348802022 @default.
• W1996934880 countsByYear W19969348802023 @default.
• W1996934880 crossrefType "journal-article" @default.
• W1996934880 hasAuthorship W1996934880A5017898982 @default.
• W1996934880 hasAuthorship W1996934880A5019004714 @default.
• W1996934880 hasAuthorship W1996934880A5023502084 @default.
• W1996934880 hasAuthorship W1996934880A5024410377 @default.
• W1996934880 hasAuthorship W1996934880A5027781711 @default.
• W1996934880 hasAuthorship W1996934880A5033191945 @default.
• W1996934880 hasAuthorship W1996934880A5064129181 @default.
• W1996934880 hasAuthorship W1996934880A5064917774 @default.
• W1996934880 hasConcept C104819515 @default.
• W1996934880 hasConcept C112613896 @default.
• W1996934880 hasConcept C121608353 @default.
• W1996934880 hasConcept C126322002 @default.
• W1996934880 hasConcept C15083742 @default.
• W1996934880 hasConcept C155672457 @default.
• W1996934880 hasConcept C171250308 @default.
• W1996934880 hasConcept C178790620 @default.
• W1996934880 hasConcept C185592680 @default.
• W1996934880 hasConcept C192562407 @default.
• W1996934880 hasConcept C202751555 @default.
• W1996934880 hasConcept C2778227246 @default.
• W1996934880 hasConcept C2780035454 @default.
• W1996934880 hasConcept C502942594 @default.
• W1996934880 hasConcept C521977710 @default.
• W1996934880 hasConcept C55493867 @default.
• W1996934880 hasConcept C71924100 @default.
• W1996934880 hasConcept C96232424 @default.
• W1996934880 hasConcept C98274493 @default.
• W1996934880 hasConceptScore W1996934880C104819515 @default.
• W1996934880 hasConceptScore W1996934880C112613896 @default.
• W1996934880 hasConceptScore W1996934880C121608353 @default.
• W1996934880 hasConceptScore W1996934880C126322002 @default.

• next