Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996941066> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1996941066 endingPage "216" @default.
- W1996941066 startingPage "209" @default.
- W1996941066 abstract "Purpose of review In the era of personalized medicine, oncologists seek to tailor treatments for their patients based on indicators of differential response to treatment. We first provide a conceptual explanation of heterogeneity of treatment effect using prostate cancer as a case study and review studies that test whether Gleason score has a role in modifying the effectiveness of androgen deprivation therapy in men newly diagnosed with metastatic prostate cancer. Recent findings Depending on the study design, setting, and population, the median time to develop castration-resistant prostate cancer ranges from 12 to 23 months among men with M1 disease on androgen deprivation therapy, and the median time from diagnosis to mortality in such patients ranges from 23 to 37 months. Patients with higher Gleason scores have a significantly shorter time to developing castration-resistant prostate cancer compared with patients with lower Gleason scores. However, data suggest that Gleason score does not have a role in modifying the survival benefit associated with androgen deprivation therapy. Summary Androgen deprivation therapy has heterogeneous effects in men with metastatic prostate cancer related to the time of developing castration resistance. However, survival benefit from androgen deprivation therapy does not appear to depend on Gleason score." @default.
- W1996941066 created "2016-06-24" @default.
- W1996941066 creator A5011882075 @default.
- W1996941066 creator A5024145910 @default.
- W1996941066 creator A5027695585 @default.
- W1996941066 date "2015-05-01" @default.
- W1996941066 modified "2023-10-18" @default.
- W1996941066 title "Understanding heterogeneity of treatment effect in prostate cancer" @default.
- W1996941066 cites W1542345927 @default.
- W1996941066 cites W1919183147 @default.
- W1996941066 cites W1975301241 @default.
- W1996941066 cites W2003985632 @default.
- W1996941066 cites W2005958584 @default.
- W1996941066 cites W2013898162 @default.
- W1996941066 cites W2014145760 @default.
- W1996941066 cites W2020861673 @default.
- W1996941066 cites W2022564653 @default.
- W1996941066 cites W2031365833 @default.
- W1996941066 cites W2033121125 @default.
- W1996941066 cites W2033261019 @default.
- W1996941066 cites W2037229475 @default.
- W1996941066 cites W2056534737 @default.
- W1996941066 cites W2064799866 @default.
- W1996941066 cites W2083134957 @default.
- W1996941066 cites W2084521917 @default.
- W1996941066 cites W2104446990 @default.
- W1996941066 cites W2107020034 @default.
- W1996941066 cites W2121863992 @default.
- W1996941066 cites W2132315278 @default.
- W1996941066 cites W2154779071 @default.
- W1996941066 cites W2161619512 @default.
- W1996941066 cites W2164821482 @default.
- W1996941066 cites W2168574474 @default.
- W1996941066 cites W4205145397 @default.
- W1996941066 cites W49263098 @default.
- W1996941066 doi "https://doi.org/10.1097/cco.0000000000000172" @default.
- W1996941066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25689354" @default.
- W1996941066 hasPublicationYear "2015" @default.
- W1996941066 type Work @default.
- W1996941066 sameAs 1996941066 @default.
- W1996941066 citedByCount "17" @default.
- W1996941066 countsByYear W19969410662015 @default.
- W1996941066 countsByYear W19969410662016 @default.
- W1996941066 countsByYear W19969410662018 @default.
- W1996941066 countsByYear W19969410662019 @default.
- W1996941066 countsByYear W19969410662020 @default.
- W1996941066 countsByYear W19969410662021 @default.
- W1996941066 countsByYear W19969410662022 @default.
- W1996941066 countsByYear W19969410662023 @default.
- W1996941066 crossrefType "journal-article" @default.
- W1996941066 hasAuthorship W1996941066A5011882075 @default.
- W1996941066 hasAuthorship W1996941066A5024145910 @default.
- W1996941066 hasAuthorship W1996941066A5027695585 @default.
- W1996941066 hasConcept C121608353 @default.
- W1996941066 hasConcept C126322002 @default.
- W1996941066 hasConcept C126894567 @default.
- W1996941066 hasConcept C143998085 @default.
- W1996941066 hasConcept C2777899217 @default.
- W1996941066 hasConcept C2777911890 @default.
- W1996941066 hasConcept C2779134260 @default.
- W1996941066 hasConcept C2780192828 @default.
- W1996941066 hasConcept C2908647359 @default.
- W1996941066 hasConcept C71315377 @default.
- W1996941066 hasConcept C71924100 @default.
- W1996941066 hasConcept C99454951 @default.
- W1996941066 hasConceptScore W1996941066C121608353 @default.
- W1996941066 hasConceptScore W1996941066C126322002 @default.
- W1996941066 hasConceptScore W1996941066C126894567 @default.
- W1996941066 hasConceptScore W1996941066C143998085 @default.
- W1996941066 hasConceptScore W1996941066C2777899217 @default.
- W1996941066 hasConceptScore W1996941066C2777911890 @default.
- W1996941066 hasConceptScore W1996941066C2779134260 @default.
- W1996941066 hasConceptScore W1996941066C2780192828 @default.
- W1996941066 hasConceptScore W1996941066C2908647359 @default.
- W1996941066 hasConceptScore W1996941066C71315377 @default.
- W1996941066 hasConceptScore W1996941066C71924100 @default.
- W1996941066 hasConceptScore W1996941066C99454951 @default.
- W1996941066 hasIssue "3" @default.
- W1996941066 hasLocation W19969410661 @default.
- W1996941066 hasLocation W19969410662 @default.
- W1996941066 hasOpenAccess W1996941066 @default.
- W1996941066 hasPrimaryLocation W19969410661 @default.
- W1996941066 hasRelatedWork W1968359514 @default.
- W1996941066 hasRelatedWork W2005958584 @default.
- W1996941066 hasRelatedWork W2030067263 @default.
- W1996941066 hasRelatedWork W2071161597 @default.
- W1996941066 hasRelatedWork W2078067450 @default.
- W1996941066 hasRelatedWork W2157750797 @default.
- W1996941066 hasRelatedWork W2811482540 @default.
- W1996941066 hasRelatedWork W2913942481 @default.
- W1996941066 hasRelatedWork W4319748405 @default.
- W1996941066 hasRelatedWork W2554788055 @default.
- W1996941066 hasVolume "27" @default.
- W1996941066 isParatext "false" @default.
- W1996941066 isRetracted "false" @default.
- W1996941066 magId "1996941066" @default.
- W1996941066 workType "article" @default.