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- W1996943732 abstract "We investigated the effects of pretransplant anti-CD4 monoclonal antibody (mAb) combined with human (h) CTLA4Ig on the survival of hamster heart and liver xenografts. Pretransplant anti-CD4 mAb (5 mg/kg × 4 days) or hCTLA4Ig (0.5 mg/rat on days 1, 3, and 5 after transplantation) treatment alone prolonged the survival of hamster liver xenografts in Lewis rats (mean survival time [MST]=10.5 days, n=6, and MST=9.0 days, n=5, respectively, compared with untreated Lewis recipients of hamster liver grafts, MST=6.0 days, n=6). The same regimen could not prevent hamster heart xenorejection. Pretransplant anti-CD4 mAb (5 mg/kg × 4 days) combined with hCTLA4Ig (0.5 mg/rat ×4) treatments increased survival of hamster liver xenograft fourfold (MST=24.2 days, n=5). The current results also show that IgG in the sera from Lewis recipients of hamster liver grafts treated with anti-CD4 mAb and hCTLA4Ig was threefold reduced at 6 days after transplantation compared with untreated Lewis rats. These results suggest a synergistic effect of anti-CD4 mAb combined with hCTLA4Ig in a liver xenograft transplantation model." @default.
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- W1996943732 date "1997-07-01" @default.
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- W1996943732 title "EFFECT OF ANTI-CD4 MONOCLONAL ANTIBODY COMBINED WITH HUMAN CTLA4Ig ON THE SURVIVAL OF HAMSTER LIVER AND HEART XENOGRAFTS IN LEWIS RATS" @default.
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- W1996943732 doi "https://doi.org/10.1097/00007890-199707270-00024" @default.
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