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- W1996946595 abstract "The NINDS trial demonstrated for the first time the effectiveness of intravenous thrombolysis in improving outcome after acute ischemic stroke. The absolute benefit of this intervention was 11-13% greater chance of being normal or near normal (MRS ≤ 1) at 3 months. However, if patients with severe stroke were considered (NIHSS ≥ 20), the absolute benefit dropped to 5-6%, indicating that IV thrombolysis may not be as effective for large vessel occlusion. This observation was further supported by TCD studies that clearly demonstrated that large artery occlusions had a recanalization rate of 13-18% with IV rt-PA. Intra-arterial thrombolysis achieves recanalization rates of 60-70%. Since tissue viability is clearly important, it is time to stop defining rigid time windows and if there is a large penumbra (20-50%) and the occlusion is in a large artery, there exists a logic and a growing evidence to consider either bridge therapy or direct intra-arterial therapy." @default.
- W1996946595 created "2016-06-24" @default.
- W1996946595 creator A5028991610 @default.
- W1996946595 creator A5031880854 @default.
- W1996946595 date "2010-01-01" @default.
- W1996946595 modified "2023-10-16" @default.
- W1996946595 title "Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset" @default.
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- W1996946595 doi "https://doi.org/10.5114/aoms.2010.14248" @default.
- W1996946595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3282505" @default.
- W1996946595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22371764" @default.
- W1996946595 hasPublicationYear "2010" @default.
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