FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996958178> ?p ?o ?g. }

• W1996958178 endingPage "e9025" @default.
• W1996958178 startingPage "e9025" @default.
• W1996958178 abstract "There is widespread concern that H5N1 avian influenza A viruses will emerge as a pandemic threat, if they become capable of human-to-human (H2H) transmission. Avian strains lack this capability, which suggests that it requires important adaptive mutations. We performed a large-scale comparative analysis of proteins from avian and human strains, to produce a catalogue of mutations associated with H2H transmissibility, and to detect their presence in avian isolates.We constructed a dataset of influenza A protein sequences from 92,343 public database records. Human and avian sequence subsets were compared, using a method based on mutual information, to identify characteristic sites where human isolates present conserved mutations. The resulting catalogue comprises 68 characteristic sites in eight internal proteins. Subtype variability prevented the identification of adaptive mutations in the hemagglutinin and neuraminidase proteins. The high number of sites in the ribonucleoprotein complex suggests interdependence between mutations in multiple proteins. Characteristic sites are often clustered within known functional regions, suggesting their functional roles in cellular processes. By isolating and concatenating characteristic site residues, we defined adaptation signatures, which summarize the adaptive potential of specific isolates. Most adaptive mutations emerged within three decades after the 1918 pandemic, and have remained remarkably stable thereafter. Two lineages with stable internal protein constellations have circulated among humans without reassorting. On the contrary, H5N1 avian and swine viruses reassort frequently, causing both gains and losses of adaptive mutations.Human host adaptation appears to be complex and systemic, involving nearly all influenza proteins. Adaptation signatures suggest that the ability of H5N1 strains to infect humans is related to the presence of an unusually high number of adaptive mutations. However, these mutations appear unstable, suggesting low pandemic potential of H5N1 in its current form. In addition, adaptation signatures indicate that pandemic H1N1/09 strain possesses multiple human-transmissibility mutations, though not an unusually high number with respect to swine strains that infected humans in the past. Adaptation signatures provide a novel tool for identifying zoonotic strains with the potential to infect humans." @default.
• W1996958178 created "2016-06-24" @default.
• W1996958178 creator A5008451966 @default.
• W1996958178 creator A5008594188 @default.
• W1996958178 creator A5011821997 @default.
• W1996958178 creator A5037664479 @default.
• W1996958178 creator A5052502655 @default.
• W1996958178 creator A5089063979 @default.
• W1996958178 creator A5090041916 @default.
• W1996958178 date "2010-02-03" @default.
• W1996958178 modified "2023-10-18" @default.
• W1996958178 title "Complete-Proteome Mapping of Human Influenza A Adaptive Mutations: Implications for Human Transmissibility of Zoonotic Strains" @default.
• W1996958178 cites W1501568954 @default.
• W1996958178 cites W1512317716 @default.
• W1996958178 cites W1546151618 @default.
• W1996958178 cites W1566744867 @default.
• W1996958178 cites W1571866243 @default.
• W1996958178 cites W1603867145 @default.
• W1996958178 cites W1964458297 @default.
• W1996958178 cites W1967756628 @default.
• W1996958178 cites W1970896735 @default.
• W1996958178 cites W1971447305 @default.
• W1996958178 cites W1978017891 @default.
• W1996958178 cites W1980344398 @default.
• W1996958178 cites W1980663785 @default.
• W1996958178 cites W1995875735 @default.
• W1996958178 cites W1997384263 @default.
• W1996958178 cites W1997972646 @default.
• W1996958178 cites W1998800643 @default.
• W1996958178 cites W2008217730 @default.
• W1996958178 cites W2013117253 @default.
• W1996958178 cites W2014348868 @default.
• W1996958178 cites W2018234381 @default.
• W1996958178 cites W2023606707 @default.
• W1996958178 cites W2024970913 @default.
• W1996958178 cites W2028372889 @default.
• W1996958178 cites W2042777577 @default.
• W1996958178 cites W2045934762 @default.
• W1996958178 cites W2050345463 @default.
• W1996958178 cites W2056297672 @default.
• W1996958178 cites W2056732680 @default.
• W1996958178 cites W2060333218 @default.
• W1996958178 cites W2061032348 @default.
• W1996958178 cites W2062869638 @default.
• W1996958178 cites W2067341120 @default.
• W1996958178 cites W2067812760 @default.
• W1996958178 cites W2069032028 @default.
• W1996958178 cites W2078796009 @default.
• W1996958178 cites W2081480299 @default.
• W1996958178 cites W2081949838 @default.
• W1996958178 cites W2083437974 @default.
• W1996958178 cites W2088108228 @default.
• W1996958178 cites W2092097938 @default.
• W1996958178 cites W2095605342 @default.
• W1996958178 cites W2095847051 @default.
• W1996958178 cites W2096525273 @default.
• W1996958178 cites W2103093438 @default.
• W1996958178 cites W2104568825 @default.
• W1996958178 cites W2105642217 @default.
• W1996958178 cites W2106483921 @default.
• W1996958178 cites W2107310295 @default.
• W1996958178 cites W2108075163 @default.
• W1996958178 cites W2113419754 @default.
• W1996958178 cites W2123271650 @default.
• W1996958178 cites W2126303830 @default.
• W1996958178 cites W2132926880 @default.
• W1996958178 cites W2143262622 @default.
• W1996958178 cites W2147754794 @default.
• W1996958178 cites W2148447408 @default.
• W1996958178 cites W2149641160 @default.
• W1996958178 cites W2157725602 @default.
• W1996958178 cites W2160881014 @default.
• W1996958178 cites W2161062388 @default.
• W1996958178 cites W2166582607 @default.
• W1996958178 cites W2167444679 @default.
• W1996958178 cites W2167853625 @default.
• W1996958178 cites W2168020376 @default.
• W1996958178 cites W2312463092 @default.
• W1996958178 cites W2380196741 @default.
• W1996958178 cites W52780145 @default.
• W1996958178 doi "https://doi.org/10.1371/journal.pone.0009025" @default.
• W1996958178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2815782" @default.
• W1996958178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20140252" @default.
• W1996958178 hasPublicationYear "2010" @default.
• W1996958178 type Work @default.
• W1996958178 sameAs 1996958178 @default.
• W1996958178 citedByCount "74" @default.
• W1996958178 countsByYear W19969581782012 @default.
• W1996958178 countsByYear W19969581782013 @default.
• W1996958178 countsByYear W19969581782014 @default.
• W1996958178 countsByYear W19969581782015 @default.
• W1996958178 countsByYear W19969581782016 @default.
• W1996958178 countsByYear W19969581782017 @default.
• W1996958178 countsByYear W19969581782018 @default.
• W1996958178 countsByYear W19969581782019 @default.
• W1996958178 countsByYear W19969581782020 @default.
• W1996958178 countsByYear W19969581782021 @default.
• W1996958178 countsByYear W19969581782022 @default.

• next