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- W1996971900 abstract "Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributable to the C-lobe and that all major virus subtypes, including H1N1 and H3N2, are inhibited. By far-western blotting and sequencing studies, we demonstrate that bLf C-lobe strongly binds to the HA(2) region of viral hemagglutinin, precisely the highly conserved region containing the fusion peptide. By molecular docking studies, three C-lobe fragments were identified which inhibited virus hemagglutination and infection at fentomolar concentration range. Besides contributing to explain the broad anti-influenza activity of bLf, our findings lay the foundations for exploiting bLf fragments as source of potential anti-influenza therapeutics." @default.
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- W1996971900 date "2012-03-01" @default.
- W1996971900 modified "2023-10-13" @default.
- W1996971900 title "Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus" @default.
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- W1996971900 doi "https://doi.org/10.1179/2047773212y.0000000004" @default.
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