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• W1996972628 abstract "The ER-localized chaperone glucose-regulated protein (GRP78) protects neurons against excitotoxicity and apoptosis. Here we show that overexpressing GRP78 protects N2a cells against mutant huntingtin proteins, reduces formation of mutant huntingtin aggregates, inhibits caspase-12 activation and blocks cell death. Our data suggest that GRP78 may be a promising therapeutic target for the treatment of Huntington's disease." @default.
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• W1996972628 date "2012-05-01" @default.
• W1996972628 modified "2023-10-18" @default.
• W1996972628 title "GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins" @default.
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• W1996972628 doi "https://doi.org/10.1016/j.neulet.2012.03.074" @default.
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