FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996972667> ?p ?o ?g. }

• W1996972667 endingPage "310" @default.
• W1996972667 startingPage "304" @default.
• W1996972667 abstract "Background Earlier prospective studies have identified insulin action and secretion as predictors of T2DM in populations with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) (2-h OGTT < 7.8 and 7.8–11 mmol/L, respectively). Fasting plasma glucose (FPG), an additional and recently modified (normal <5.6 mmol/L) diagnostic criterion is associated with insulin secretion. We wanted to establish whether insulin secretion persists as an independent predictor of T2DM in individuals with no clinical evidence of impaired glucose regulation based on FPG and 2-h plasma glucose concentrations. Methods Insulin action (M, euglycemic-hyperinsulinemic clamp), insulin secretion (acute insulin response (AIR), IVGTT), and adiposity (%Fat, DXA or densitometry) were compared at baseline in 358 Pima Indians (232M/126F, 18–44 years old) with normal glucose regulation of whom 61 (35M/26F) developed diabetes (DIAB) during a median follow-up time of 7.6 years. Results In proportional-hazard analysis, % Fat (HR = 1.52, p = 0.03), M (HR = 0.51, p = 0.04) and AIR (HR = 0.64, p = 0.003) predicted the development of diabetes after adjustment for age and sex. In regression analysis adjusting for age, sex, %Fat and M at baseline, the non-diabetic group (NON-DM) had a higher AIR (p = 0.0002) than the DIAB group; the positive association of AIR with adiposity observed in the NON-DM group was absent in the DIAB group. Cumulative incidence rates (12y) for diabetes were highest (48%) in subjects with both M and AIR below the population median and lowest (11%) in subjects with both M and AIR above the population median. Conclusion AIR can predict diabetes prior to the current clinical indicators of impaired glucose regulation. Published in 2006 by John Wiley & Sons, Ltd. John Wiley & Sons, Ltd." @default.
• W1996972667 created "2016-06-24" @default.
• W1996972667 creator A5017134187 @default.
• W1996972667 creator A5024427633 @default.
• W1996972667 creator A5050165878 @default.
• W1996972667 creator A5052309689 @default.
• W1996972667 creator A5058624350 @default.
• W1996972667 date "2007-01-01" @default.
• W1996972667 modified "2023-10-14" @default.
• W1996972667 title "Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations" @default.
• W1996972667 cites W1585178855 @default.
• W1996972667 cites W1968766654 @default.
• W1996972667 cites W1968806474 @default.
• W1996972667 cites W1976255906 @default.
• W1996972667 cites W1984297603 @default.
• W1996972667 cites W2006433855 @default.
• W1996972667 cites W2020734415 @default.
• W1996972667 cites W2022852506 @default.
• W1996972667 cites W2033125833 @default.
• W1996972667 cites W2037148639 @default.
• W1996972667 cites W2049107834 @default.
• W1996972667 cites W2051313176 @default.
• W1996972667 cites W2055872273 @default.
• W1996972667 cites W2067667836 @default.
• W1996972667 cites W2077149049 @default.
• W1996972667 cites W2078073869 @default.
• W1996972667 cites W2082013725 @default.
• W1996972667 cites W2102264499 @default.
• W1996972667 cites W2102844001 @default.
• W1996972667 cites W2109711319 @default.
• W1996972667 cites W2111493733 @default.
• W1996972667 cites W2118238620 @default.
• W1996972667 cites W2118267307 @default.
• W1996972667 cites W2120305681 @default.
• W1996972667 cites W2121879147 @default.
• W1996972667 cites W2131136365 @default.
• W1996972667 cites W2132681327 @default.
• W1996972667 cites W2135298791 @default.
• W1996972667 cites W2142025433 @default.
• W1996972667 cites W2148688487 @default.
• W1996972667 cites W2158822657 @default.
• W1996972667 cites W2167420234 @default.
• W1996972667 cites W2171407792 @default.
• W1996972667 cites W2185461071 @default.
• W1996972667 cites W2332951586 @default.
• W1996972667 cites W2334309509 @default.
• W1996972667 cites W3023173633 @default.
• W1996972667 cites W4233562854 @default.
• W1996972667 cites W4234663921 @default.
• W1996972667 cites W4321059897 @default.
• W1996972667 doi "https://doi.org/10.1002/dmrr.686" @default.
• W1996972667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2128254" @default.
• W1996972667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17001619" @default.
• W1996972667 hasPublicationYear "2007" @default.
• W1996972667 type Work @default.
• W1996972667 sameAs 1996972667 @default.
• W1996972667 citedByCount "48" @default.
• W1996972667 countsByYear W19969726672012 @default.
• W1996972667 countsByYear W19969726672013 @default.
• W1996972667 countsByYear W19969726672014 @default.
• W1996972667 countsByYear W19969726672015 @default.
• W1996972667 countsByYear W19969726672016 @default.
• W1996972667 countsByYear W19969726672017 @default.
• W1996972667 countsByYear W19969726672018 @default.
• W1996972667 countsByYear W19969726672019 @default.
• W1996972667 countsByYear W19969726672021 @default.
• W1996972667 countsByYear W19969726672022 @default.
• W1996972667 crossrefType "journal-article" @default.
• W1996972667 hasAuthorship W1996972667A5017134187 @default.
• W1996972667 hasAuthorship W1996972667A5024427633 @default.
• W1996972667 hasAuthorship W1996972667A5050165878 @default.
• W1996972667 hasAuthorship W1996972667A5052309689 @default.
• W1996972667 hasAuthorship W1996972667A5058624350 @default.
• W1996972667 hasBestOaLocation W19969726672 @default.
• W1996972667 hasConcept C126322002 @default.
• W1996972667 hasConcept C134018914 @default.
• W1996972667 hasConcept C2777180221 @default.
• W1996972667 hasConcept C2779306644 @default.
• W1996972667 hasConcept C2780609358 @default.
• W1996972667 hasConcept C2908647359 @default.
• W1996972667 hasConcept C555293320 @default.
• W1996972667 hasConcept C71924100 @default.
• W1996972667 hasConcept C99454951 @default.
• W1996972667 hasConceptScore W1996972667C126322002 @default.
• W1996972667 hasConceptScore W1996972667C134018914 @default.
• W1996972667 hasConceptScore W1996972667C2777180221 @default.
• W1996972667 hasConceptScore W1996972667C2779306644 @default.
• W1996972667 hasConceptScore W1996972667C2780609358 @default.
• W1996972667 hasConceptScore W1996972667C2908647359 @default.
• W1996972667 hasConceptScore W1996972667C555293320 @default.
• W1996972667 hasConceptScore W1996972667C71924100 @default.
• W1996972667 hasConceptScore W1996972667C99454951 @default.
• W1996972667 hasIssue "4" @default.
• W1996972667 hasLocation W19969726671 @default.
• W1996972667 hasLocation W19969726672 @default.
• W1996972667 hasLocation W19969726673 @default.
• W1996972667 hasLocation W19969726674 @default.
• W1996972667 hasOpenAccess W1996972667 @default.

• next