Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996975096> ?p ?o ?g. }
- W1996975096 endingPage "6463" @default.
- W1996975096 startingPage "6459" @default.
- W1996975096 abstract "A series of tetrasubstituted naphthalene diimide compounds with N-methylpiperazine end groups has been synthesized and evaluated as G-quadruplex ligands. They have high affinity and selectivity for telomeric G-quadruplex DNA over duplex DNA. CD studies show that they induce formation of a parallel G-quadruplex topology. They inhibit the binding of hPOT1 and topoisomerase IIIα to telomeric DNA and inhibit telomerase activity in MCF7 cells. The compounds have potent activity in a panel of cancer cell lines, with typical IC(50) values of ∼0.1 μM, and up to 100-fold lower toxicity in a normal human fibroblast cell line." @default.
- W1996975096 created "2016-06-24" @default.
- W1996975096 creator A5003587331 @default.
- W1996975096 creator A5017682764 @default.
- W1996975096 creator A5027498388 @default.
- W1996975096 creator A5060982408 @default.
- W1996975096 creator A5081675801 @default.
- W1996975096 date "2010-11-01" @default.
- W1996975096 modified "2023-09-30" @default.
- W1996975096 title "Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells" @default.
- W1996975096 cites W1976548990 @default.
- W1996975096 cites W1979395573 @default.
- W1996975096 cites W1981888951 @default.
- W1996975096 cites W1990635146 @default.
- W1996975096 cites W1993469796 @default.
- W1996975096 cites W1999110382 @default.
- W1996975096 cites W2000971601 @default.
- W1996975096 cites W2008120871 @default.
- W1996975096 cites W2009139426 @default.
- W1996975096 cites W2014013625 @default.
- W1996975096 cites W2025615481 @default.
- W1996975096 cites W2025811126 @default.
- W1996975096 cites W2028345897 @default.
- W1996975096 cites W2035953002 @default.
- W1996975096 cites W2039824579 @default.
- W1996975096 cites W2045660156 @default.
- W1996975096 cites W2048165645 @default.
- W1996975096 cites W2050971157 @default.
- W1996975096 cites W2053166926 @default.
- W1996975096 cites W2060017837 @default.
- W1996975096 cites W2063733156 @default.
- W1996975096 cites W2077779709 @default.
- W1996975096 cites W2092324565 @default.
- W1996975096 cites W2092452241 @default.
- W1996975096 cites W2099186751 @default.
- W1996975096 cites W2101052607 @default.
- W1996975096 cites W2110289461 @default.
- W1996975096 cites W2114962272 @default.
- W1996975096 cites W2115732372 @default.
- W1996975096 cites W2116609429 @default.
- W1996975096 cites W2123525790 @default.
- W1996975096 cites W2127213026 @default.
- W1996975096 cites W2128366005 @default.
- W1996975096 cites W2128856714 @default.
- W1996975096 cites W2145357417 @default.
- W1996975096 cites W2153164448 @default.
- W1996975096 cites W2160185049 @default.
- W1996975096 cites W2163134391 @default.
- W1996975096 cites W2165570610 @default.
- W1996975096 cites W2166630132 @default.
- W1996975096 cites W2167223269 @default.
- W1996975096 cites W2171830519 @default.
- W1996975096 cites W2172060739 @default.
- W1996975096 cites W2951024110 @default.
- W1996975096 doi "https://doi.org/10.1016/j.bmcl.2010.09.066" @default.
- W1996975096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20932753" @default.
- W1996975096 hasPublicationYear "2010" @default.
- W1996975096 type Work @default.
- W1996975096 sameAs 1996975096 @default.
- W1996975096 citedByCount "91" @default.
- W1996975096 countsByYear W19969750962012 @default.
- W1996975096 countsByYear W19969750962013 @default.
- W1996975096 countsByYear W19969750962014 @default.
- W1996975096 countsByYear W19969750962015 @default.
- W1996975096 countsByYear W19969750962016 @default.
- W1996975096 countsByYear W19969750962017 @default.
- W1996975096 countsByYear W19969750962018 @default.
- W1996975096 countsByYear W19969750962019 @default.
- W1996975096 countsByYear W19969750962020 @default.
- W1996975096 countsByYear W19969750962021 @default.
- W1996975096 countsByYear W19969750962022 @default.
- W1996975096 countsByYear W19969750962023 @default.
- W1996975096 crossrefType "journal-article" @default.
- W1996975096 hasAuthorship W1996975096A5003587331 @default.
- W1996975096 hasAuthorship W1996975096A5017682764 @default.
- W1996975096 hasAuthorship W1996975096A5027498388 @default.
- W1996975096 hasAuthorship W1996975096A5060982408 @default.
- W1996975096 hasAuthorship W1996975096A5081675801 @default.
- W1996975096 hasConcept C104317684 @default.
- W1996975096 hasConcept C118792377 @default.
- W1996975096 hasConcept C121608353 @default.
- W1996975096 hasConcept C147897179 @default.
- W1996975096 hasConcept C161790260 @default.
- W1996975096 hasConcept C177336024 @default.
- W1996975096 hasConcept C185592680 @default.
- W1996975096 hasConcept C54355233 @default.
- W1996975096 hasConcept C552990157 @default.
- W1996975096 hasConcept C55493867 @default.
- W1996975096 hasConcept C71240020 @default.
- W1996975096 hasConcept C81885089 @default.
- W1996975096 hasConcept C83762044 @default.
- W1996975096 hasConcept C86803240 @default.
- W1996975096 hasConcept C94581717 @default.
- W1996975096 hasConcept C96232424 @default.
- W1996975096 hasConceptScore W1996975096C104317684 @default.
- W1996975096 hasConceptScore W1996975096C118792377 @default.
- W1996975096 hasConceptScore W1996975096C121608353 @default.
- W1996975096 hasConceptScore W1996975096C147897179 @default.