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• W1996975123 abstract "Cerebroprotection after administration of glutamate receptor antagonists has been well documented. The present study is intended to determine whether the non-competitive α-amino-3-hydroxy-methyl-4-isoxazolyl-propionic acid (AMPA) receptor antagonist talampanel, known as antiepileptic drug, has neuroprotective effects in stroke models in rodents. The infarct size was measured in three models of stroke by 2,3,5-triphenyltetrazolium chloride staining. Therapeutic time window was also examined in rats subjected to 1 h middle cerebral artery occlusion. The degree of neuroprotection was tested in mice, using 1.5, 2 h or permanent middle cerebral artery occlusions. Effect on photochemically induced thrombosis was investigated in rats applying 30 min time window after brain irradiation. Talampanel reduced the infarct size by 47.3% (p < 0.01) after a 30 min delay and 48.5% (p < 0.01) after 2 h delay following middle cerebral artery occlusion in rats. In mice, talampanel reduced the extension of the infarcted tissue at the levels of striatum and hippocampus by 44.5% (p < 0.05) and 39.3% (p < 0.01) after 1.5 h transient ischemia and still caused 37.0% (p < 0.05) and 37.0% (p < 0.05) inhibitions when 2 h occlusion was applied. In photothrombosis talampanel showed a 40.1% (p < 0.05) inhibition. Protective actions of talampanel in various stroke models, in rats and mice, suggest a possible therapeutic role of the compound in stroke patients." @default.
• W1996975123 created "2016-06-24" @default.
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• W1996975123 date "2005-07-01" @default.
• W1996975123 modified "2023-10-18" @default.
• W1996975123 title "The AMPA-antagonist talampanel is neuroprotective in rodent models of focal cerebral ischemia" @default.
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• W1996975123 doi "https://doi.org/10.1016/j.brainresbull.2005.03.012" @default.
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